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Titolo:
Quantitation of the factor VII- and single-chain plasminogen activator-activating protease in plasmas of healthy subjects
Autore:
Romisch, J; Feussner, A; Stohr, HA;
Indirizzi:
Aventis Behring GmbH, Res, D-35002 Marburg, Germany Aventis Behring GmbH Marburg Germany D-35002 s, D-35002 Marburg, Germany
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 5, volume: 12, anno: 2001,
pagine: 375 - 383
SICI:
0957-5235(200107)12:5<375:QOTFVA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALURONAN-BINDING PROTEIN; SERINE-PROTEASE; TISSUE FACTOR; PHBP; PURIFICATION;
Keywords:
FVII activating protease; single-chain plasminogen activator activating potency; plasma hyaluronan binding protein; healthy subjects; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Romisch, J Aventis Behring GmbH, Res, POB 1230, D-35002 Marburg, Germany Aventis Behring GmbH POB 1230 Marburg Germany D-35002 Germany
Citazione:
J. Romisch et al., "Quantitation of the factor VII- and single-chain plasminogen activator-activating protease in plasmas of healthy subjects", BL COAG FIB, 12(5), 2001, pp. 375-383

Abstract

Plasma samples of 189 healthy subjects were investigated for antigen levels of the recently reported factor VII- and single-chain plasminogen activator-activating protease (FSAP) and the corresponding pro-urokinase activating potencies. While the age of donors had no significant effect on the investigated parameters, female plasmas revealed a trend to higher antigen contents and activity levels. Surprisingly, as much as 9% of all samples contained significantly reduced single-chain urinary plasminogen activator activating potential, whereas antigen concentrations were normal. Additionally, 1%of the plasmas was found to decrease in both FSAP anti cn and activity contents. FSAP of three subjects displaying reduced activities throughout a follow-up period of 6 months were purified from plasmas and were characterized. As compared with pool plasma derived FSAP, investigation of the individual preparations confirmed their reduced potency to activate pro-urokinase. However, factor VII activation was not affected. It is speculated that the FSAP binding site for single-chain plasminogen activators is affected, potentially by as yet unknown polymorphism(s) or mutation(s). (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:39:55