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Titolo:
Low molecular weight heparin prevents activation of coagulation in a hypobaric environment
Autore:
Bendz, B; Sevre, K; Andersen, TO; Sandset, PM;
Indirizzi:
Univ Oslo, Ulleval Hosp, Haematol Res Lab, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 Hosp, Haematol Res Lab, N-0407 Oslo, Norway
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 5, volume: 12, anno: 2001,
pagine: 371 - 374
SICI:
0957-5235(200107)12:5<371:LMWHPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR PATHWAY INHIBITOR; ECONOMY CLASS SYNDROME; VENOUS THROMBOEMBOLISM; AIR-TRAVEL; RISK-FACTORS; THROMBOSIS; ASSOCIATION; ENOXAPARIN; FLIGHT; ASSAY;
Keywords:
anti-activated factor X activity; hypobaric hypoxia; low molecular weight heparin; prothrombin fragments 1+2; thrombin-antithrombin complex; tissue factor pathway inhibitor; travel; thromboprophylaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bendz, B Univ Oslo, Ulleval Hosp, Haematol Res Lab, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 matol Res Lab, N-0407 Oslo, Norway
Citazione:
B. Bendz et al., "Low molecular weight heparin prevents activation of coagulation in a hypobaric environment", BL COAG FIB, 12(5), 2001, pp. 371-374

Abstract

It is commonly thought that people are at increased risk of venous thrombosis during air flights, but the magnitude of the risk is unknown. Suggestedrisk factors are hypobaric hypoxia, stasis, and dehydration. In a previousexperimental study, we found immediate activation of coagulation as determined by the levels of prothrombin fragments 1 + 2 (F1+2) and thrombin-antithrombin complex (TAT) after rapid exposure to a hypobaric and hypoxic environment (76 kPa). The aim of the present study was to examine the ability oflow molecular weight heparin (LMWH) to prevent such activation. Twelve healthy male volunteers were given 40 mg enoxaparin as a single subcutaneous injection 1 h prior to exposure from 96.3 to 76 kPa. We found no activation of coagulation as judged by F1+2 or TAT. Anti-activated factor X activity levels and release of tissue factor pathway inhibitor was normal. We conclude that high prophylactic doses of a LMWH most probably prevent activation of coagulation in a hypobaric environment. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:24:55