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Titolo:
Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
Autore:
Matsuo, K; Suzuki, R; Hamajima, N; Ogura, M; Kagami, Y; Taji, H; Kondoh, E; Maeda, S; Asakura, S; Kaba, S; Nakamura, S; Seto, M; Morishima, Y; Tajima, K;
Indirizzi:
Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Div Mol Med, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Div Pathol & Genet, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Clin Lab, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Dept Hematol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Dept Chemotherapy, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Nagoya Univ, Grad Sch, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan goya Univ, Grad Sch, Nagoya, Aichi, Japan
Titolo Testata:
BLOOD
fascicolo: 10, volume: 97, anno: 2001,
pagine: 3205 - 3209
SICI:
0006-4971(20010515)97:10<3205:ABPOFA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; CORONARY-ARTERY DISEASE; DEEP-VEIN THROMBOSIS; NEURAL-TUBE DEFECTS; COLORECTAL-CANCER; RISK FACTOR; B-CELL; VASCULAR-DISEASE; COMMON MUTATION; SYNTHASE GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuo, K Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Chikusa Ku, 1-1 Kanokoden, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr 1-1 Kanokoden Nagoya Aichi Japan 4648681 1, Japan
Citazione:
K. Matsuo et al., "Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma", BLOOD, 97(10), 2001, pp. 3205-3209

Abstract

Genetic alteration is considered a probable cause of malignant lymphoma. Folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, and their metabolic pathways might thus affect disease susceptibility. In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme, methylenetetrahydrofolate reductase (MTHFR), and one was evaluated for methionine synthase (MS). The 2 polymorphisms, MTHFR677 C-->T and MTHFR1298 A-->C, are reported to reduce the enzyme activity, which causes intracellular accumulation of 5,10-methylenetetrahydrofolate and results in a reduced incidence of DNA double-strand breakage. The MS2756 A-->Gpolymorphism also reduces the enzyme activity and results in the hypomethylation of DNA. To evaluate the association between malignant lymphoma susceptibility and these polymorphisms, hospital-based case-control study was conducted in Aichi Cancer Center. Ninety-eight patients with histologically confirmed lymphoma and 243 control subjects without cancer were evaluated. Unconditional logistic regression analyses revealed a higher susceptibility with the MTHFR677 CC and the MTHFR1298 AA genotypes (odds ratio, 2.26; 95% confidence interval, 1.26-4.02) when those harboring at least one variant allele in either polymorphism of MTHFR were defined as the reference. For the MS polymorphism, the MS2756 GG genotype also showed a higher susceptibility (odds ratio, 3.83; 95% CI, 1.21-12.1) than those with MS2756 AA or AG types. The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas. Further studies to confirm the association and detailed biologic mechanisms arenow required. (Blood. 2001;97:3205-3209) (C) 2001 by The American Society of Hematology.

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Documento generato il 01/12/20 alle ore 21:46:12