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Titolo:
Expression of functional lung resistance-related protein predicts poor outcome in adult T-cell leukemia
Autore:
Ohno, N; Tani, A; Uozumi, K; Hanada, S; Furukawa, T; Akiba, S; Sumizawa, T; Utsunomiya, A; Arima, T; Akiyama, S;
Indirizzi:
Kagoshima Univ, Fac Med, Inst Canc Res, Dept Canc Chemotherapy, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 therapy, Kagoshima 8908520, Japan Kagoshima Univ, Fac Med, Dept Publ Hlth, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 bl Hlth, Kagoshima 8908520, Japan
Titolo Testata:
BLOOD
fascicolo: 4, volume: 98, anno: 2001,
pagine: 1160 - 1165
SICI:
0006-4971(20010815)98:4<1160:EOFLRP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA SW-620 CELLS; ACUTE MYELOID-LEUKEMIA; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; MULTIPLE-MYELOMA; P-GLYCOPROTEIN; VAULT PROTEIN; OVEREXPRESSION; REVERSAL; LRP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Akiyama, S Kagoshima Univ, Fac Med, Inst Canc Res, Dept Canc Chemotherapy,Sakuragaoka 8-35-1, Kagoshima 8908520, Japan Kagoshima Univ Sakuragaoka 8-35-1 Kagoshima Japan 8908520 apan
Citazione:
N. Ohno et al., "Expression of functional lung resistance-related protein predicts poor outcome in adult T-cell leukemia", BLOOD, 98(4), 2001, pp. 1160-1165

Abstract

Chemotherapy of patients with adult T-cell leukemia (ATL) has been unsuccessful. The poor outcome is thought to be caused mainly by the drug resistance of ATL cells. Lung resistance-related protein (LRP) is a novel protein associated with drug resistance. The expression of LRP messenger RNA (mRNA) was evaluated by slot blot analysis in 55 patients with ATL. Of these patients, 36 had acute, 12 chronic, and 7 lymphoma-type ATL. The expression levels of LRP mRNA were significantly higher in chronic ATL than in lymphoma-type ATL (P = .007). The expression of LRP mRNA was higher in patients with white blood cell counts above 30000/muL (P = .038) or with abnormal lymphocyte counts above 10000/muL (P = .007) than in the remaining patients. The enhanced eff lux of [C-14]doxorubicin from nuclei isolated from ATL cells that expressed high levels of LRP was inhibited by a polyclonal antibody against LRP, and the accumulation of doxorubicin in the isolated nuclei was increased by the anti-LRP antibody. In acute and lymphoma-type ATL patients, high expression of LRP mRNA at diagnosis correlated with shorter survival, and a Cox proportional hazards model showed that LRP expression is an independent prognostic factor. These findings suggest that functionally active LRPis expressed in some ATL cells and that it is involved in drug resistance and poor prognosis in ATL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:59:50