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Titolo:
Depletion of circulating natural type I interferon-producing cells in HIV-infected AIDS patients
Autore:
Soumelis, V; Scott, I; Gheyas, F; Bouhour, D; Cozon, G; Cotte, L; Huang, L; Levy, JA; Liu, YJ;
Indirizzi:
Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc Palo Alto CA USA 94304 CA 94304 USA Schering Plough Corp, Res Inst, Dept Biostat, Kenilworth, NJ USA Schering Plough Corp Kenilworth NJ USA Dept Biostat, Kenilworth, NJ USA Hospices Civils Lyon, Lyon, France Hospices Civils Lyon Lyon FranceHospices Civils Lyon, Lyon, France San Francisco Gen Hosp, San Francisco, CA 94110 USA San Francisco Gen Hosp San Francisco CA USA 94110 Francisco, CA 94110 USA
Titolo Testata:
BLOOD
fascicolo: 4, volume: 98, anno: 2001,
pagine: 906 - 912
SICI:
0006-4971(20010815)98:4<906:DOCNTI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY SYNDROME; LONG-TERM NONPROGRESSORS; PLASMACYTOID T-CELLS; DENDRITIC CELLS; OPPORTUNISTIC INFECTIONS; HUMAN MACROPHAGES; BETA-INTERFERON; HUMAN BLOOD; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Levy, JA Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 CA 94143 USA
Citazione:
V. Soumelis et al., "Depletion of circulating natural type I interferon-producing cells in HIV-infected AIDS patients", BLOOD, 98(4), 2001, pp. 906-912

Abstract

Natural interferon-alpha producing cells (IPCs) are a newly characterized blood cell type, which is the major source of type I interferons in antiviral innate immune responses. The relationship between the number of circulating IPCs, HIV disease progression, and the occurrence of HIV-related complications was investigated. The study of 25 healthy donors and 54 HIV-infected subjects demonstrated a direct correlation between blood [PC number, interferon-a production, and clinical state of HIV-infected subjects. Asymptomatic long-term survivors had increased [PC number and function relative to uninfected controls and infected individuals with progressive disease. [PC numbers were markedly reduced in AIDS patients developing opportunistic infections and cancer. A negative correlation was found between the IPC number in the blood and the HIV viral load, suggesting that IPCs are important in controlling HIV replication. This study provides the first evidence that IPCs are being affected during the course of HIV infection and suggests that these cells can play a vital role In the protection against opportunistic pathogens and cancer. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:26:48