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Titolo:
N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: Oral activity via P1 ' isobutyl substitution
Autore:
Musso, DL; Andersen, MW; Andrews, RC; Austin, R; Beaudet, EJ; Becherer, JD; Bubacz, DG; Bickett, DM; Chan, JH; Conway, JG; Cowan, DJ; Gaul, MD; Glennon, KC; Hedeen, KM; Lambert, MH; Leesnitzer, MA; McDougald, DL; Mitchell, JL; Moss, ML; Rabinowitz, MH; Rizzolio, MC; Schaller, LT; Stanford, JB; Tippin, TK; Warner, JR; Whitesell, LG; Wiethe, RW;
Indirizzi:
GlaxoSmithKline Res & Dev, Res Triangle Pk, NC 27709 USA GlaxoSmithKline Res & Dev Res Triangle Pk NC USA 27709 e Pk, NC 27709 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 16, volume: 11, anno: 2001,
pagine: 2147 - 2151
SICI:
0960-894X(20010820)11:16<2147:NPATMI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; MATRIX-METALLOPROTEINASE; RHEUMATOID-ARTHRITIS; FUSION PROTEIN; METHOTREXATE; PRECURSOR; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Musso, DL GlaxoSmithKline Res & Dev, 5 Moore Dr, Res Triangle Pk, NC 27709USA GlaxoSmithKline Res & Dev 5 Moore Dr Res Triangle Pk NC USA 27709
Citazione:
D.L. Musso et al., "N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: Oral activity via P1 ' isobutyl substitution", BIOORG MED, 11(16), 2001, pp. 2147-2151

Abstract

N-Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and TNF-x converting enzyme (TACE). Compound 13c possesses good oraland intravenous pharmacokinetics in the rat and dog. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:28:51