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Titolo:
The potential of monoclonal antibodies to reduce reperfusion injury in myocardial infarction
Autore:
McKenzie, ME; Gurbel, PA;
Indirizzi:
Sinai Ctr Thrombosis Res, Baltimore, MD 21215 USA Sinai Ctr Thrombosis Res Baltimore MD USA 21215 , Baltimore, MD 21215 USA
Titolo Testata:
BIODRUGS
fascicolo: 6, volume: 15, anno: 2001,
pagine: 395 - 404
SICI:
1173-8804(2001)15:6<395:TPOMAT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IIB/IIIA RECEPTOR BLOCKADE; LEFT-VENTRICULAR FUNCTION; LEUKOCYTE INTEGRIN MAC-1; P-SELECTIN; CORONARY ANGIOPLASTY; GLYCOPROTEIN LIGAND; ISCHEMIA; ADHESION; CELLS; MODEL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Gurbel, PA Sinai Ctr Thrombosis Res, Hoffberger Bldg,Suite 56,2401 W Belvedere Ave, Baltimore, MD 21215 USA Sinai Ctr Thrombosis Res Hoffberger Bldg,Suite 56,2401 W Belvedere Ave Baltimore MD USA 21215
Citazione:
M.E. McKenzie e P.A. Gurbel, "The potential of monoclonal antibodies to reduce reperfusion injury in myocardial infarction", BIODRUGS, 15(6), 2001, pp. 395-404

Abstract

Reperfusion injury is mediated, in part, by the accumulation of platelets and leucocytes in the microvasculature after reflow. These components of the blood pool form aggregates that can obstruct flow in small vessels. In addition, mediators released from leucocytes and platelets further damage thereperfused myocardium. A strategy to limit reperfusion injury exploits theimportant role of membrane-bound adhesion molecules that attach platelets and leucocytes to themselves and to the vascular endothelium. Monoclonal antibodies against specific adhesion receptors effectively eliminate the function of the receptor. The most widely investigated receptors are P-selectin, present on platelets and the endothelium, CD11/CD18, present on leucocytes, and the fibrinogen receptor on platelets. Numerous animal studies have strongly supported the use of these monoclonal antibodies to block adhesion receptors as adjunctive reperfusion therapy. However, recent human trials have yielded disappointing results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:25:11