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Titolo:
Gene therapy for colorectal cancer - Therapeutic potential
Autore:
Chen, MJ; Chung-Faye, GA; Searle, PF; Young, LS; Kerr, DJ;
Indirizzi:
Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TA W Midlands, England
Titolo Testata:
BIODRUGS
fascicolo: 6, volume: 15, anno: 2001,
pagine: 357 - 367
SICI:
1173-8804(2001)15:6<357:GTFCC->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENE; CARCINOEMBRYONIC ANTIGEN CEA; RECOMBINANT VACCINIA VIRUS; CYTOSINE DEAMINASE GENE; HUMAN TUMOR-CELLS; COLON-CANCER; PHASE-I; ADENOVIRUS VECTOR; CLINICAL-TRIAL; VIRAL VECTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, MJ Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TA s, England
Citazione:
M.J. Chen et al., "Gene therapy for colorectal cancer - Therapeutic potential", BIODRUGS, 15(6), 2001, pp. 357-367

Abstract

Colorectal cancer is a leading cause of cancer mortality in Western countries. Gene therapy has been proposed as a potential novel treatment modalityfor colorectal cancer, but it is still in an early stage of development. The preclinical data have been promising and numerous clinical trials are underway. This brief review aims to summarise the current status of clinical trials of different gene therapy strategies, including immune stimulation, mutant gene correction, prodrug activation and oncolytic virus therapy, forpatients with colorectal cancer. Data from phase I trials have proven the safety of the reagents but have not yet demonstrated significant therapeutic benefit. In order to achieve this and extend the scope of the treatment, continuing efforts should be made to improve the antitumour potency, efficiency of gene delivery and accuracy of gene targeting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:33:17