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Titolo:
Does Parkinson's disease have an immunological basis? The evidence and itstherapeutic implications
Autore:
Fiszer, U;
Indirizzi:
Med Ctr Postgrad Educ, Dept Neurol & Epileptol, PL-00416 Warsaw, Poland Med Ctr Postgrad Educ Warsaw Poland PL-00416 ol, PL-00416 Warsaw, Poland
Titolo Testata:
BIODRUGS
fascicolo: 6, volume: 15, anno: 2001,
pagine: 351 - 355
SICI:
1173-8804(2001)15:6<351:DPDHAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEINS; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; CEREBROSPINAL-FLUID; SUBSTANTIA-NIGRA; HUMORAL RESPONSE; GLIAL-CELLS; T-CELLS; HLA-DR; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Fiszer, U Med Ctr Postgrad Educ, Dept Neurol & Epileptol, 231 Czerniakowska Str, PL-00416 Warsaw, Poland Med Ctr Postgrad Educ 231 Czerniakowska Str Warsaw Poland PL-00416
Citazione:
U. Fiszer, "Does Parkinson's disease have an immunological basis? The evidence and itstherapeutic implications", BIODRUGS, 15(6), 2001, pp. 351-355

Abstract

Parkinson's disease (PD) is an age-related neurodegenerative movement disorder of unknown aetiology. Immune abnormalities have been described in PD including the occurrence of autoantibodies against neuronal structures and high numbers of microglia cells expressing the histocompatibility glycoprotein human leucocyte antigen-DR in the substantia nigra. An infectious cause for PD has been discussed for years. Disturbed cellular and humoral immune functions in peripheral blood of patients with PD have been also reported. An elevated gamma delta (+) T cell population and increased immunoglobulin G immunity in CSF to heat shock proteins have been found in PD. Cytokines and apoptosis-related proteins were elevated in the striatum in patients with PD. Activated glial cells may participate in neuronal cell death in PD byproviding toxic substances. We may conclude that the immune system is involved in the pathogenesis of PD. However, we are not able to determine whether the disturbances described above constitute a primary or secondary phenomenon. Immunomodulatory agents may have important applications in the development of new therapies for PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:07:28