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Titolo:
Biochemical signals and biological responses elicited by the focal adhesion kinase
Autore:
Schaller, MD;
Indirizzi:
Univ N Carolina, Dept Cell & Dev Biol, Lineberger Comprehens Canc Ctr, CtrThrombosis & Hemostasis, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 tasis, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Cell & Dev Biol, Lineberger Comprehens Canc Ctr, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 rders, Chapel Hill, NC 27599 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
fascicolo: 1, volume: 1540, anno: 2001,
pagine: 1 - 21
SICI:
0167-4889(20010725)1540:1<1:BSABRE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE-PHOSPHATASE; SRC-FAMILY KINASES; SWISS 3T3 CELLS; JUN NH2-TERMINAL KINASE; ACTIVATION LOOP PHOSPHORYLATION; INTEGRIN-MEDIATED ACTIVATION; GROWTH-FACTOR ACTIVATION; TUMOR-SUPPRESSOR GENE; CANINE KIDNEY-CELLS; C-SRC;
Keywords:
focal adhesion kinase; integrin; Src; Rho; migration; apoptosis; cancer;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Schaller, MD Univ N Carolina, Dept Cell & Dev Biol, Lineberger Comprehens Canc Ctr, CtrThrombosis & Hemostasis, 534 Taylor Hall,CB 7090, Chapel Hill,NC 27599 USA Univ N Carolina 534 Taylor Hall,CB 7090 Chapel Hill NC USA 27599
Citazione:
M.D. Schaller, "Biochemical signals and biological responses elicited by the focal adhesion kinase", BBA-MOL CEL, 1540(1), 2001, pp. 1-21

Abstract

The focal adhesion kinase, FAK, is an important component of an integrin-dependent signaling pathway, which functions to transmit signals from the extracellular matrix into the cytoplasm. FAK is an essential gene product, since the fak-/-mouse exhibits embryonic lethality. A number of important biological processes, including cell motility and cell survival, are controlled by integrin-dependent signals and FAK has been implicated in regulating these processes. This review will focus upon recent findings providing insight into the mechanisms by which FAK transmits biochemical signals and elicits biological effects. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:50:33