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Titolo:
How to prevent fractures in the individual with osteoporosis
Autore:
Javaid, MK; Cooper, C;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 497 - 515
SICI:
1521-6942(200107)15:3<497:HTPFIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; RANDOMIZED CONTROLLED TRIAL; HORMONE REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; HIP FRACTURE; VERTEBRAL FRACTURES; PARATHYROID-HORMONE; ELDERLY WOMEN; SALMON-CALCITONIN; VITAMIN-D;
Keywords:
osteoporosis; fracture; calcium; vitamin D; SERM; bisphosphonate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Javaid, MK Univ Southampton, Southampton Gen Hosp, MRC, Environm EpidemiolUnit, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD s, England
Citazione:
M.K. Javaid e C. Cooper, "How to prevent fractures in the individual with osteoporosis", BEST PR R C, 15(3), 2001, pp. 497-515

Abstract

The high rate of osteoporotic fracture in Western populations has resultedin a significant burden in terms of morbidity, mortality and health care costs. The use of DXA has made the diagnosis of osteoporosis easier and identified a subgroup of individuals who are at a higher risk of fracture. It is a useful tool in determining therapy in those at greatest risk of fracture. However, widespread use of such treatments is low and greater uptake remains an elusive goal. There are now many different treatments that reduce fracture rate, and can accompany lifestyle measures such as smoking cessation, diet and exercise. Dietary supplementation with calcium has been shown to reduce the risk of vertebral fracture, and the combination of calcium with vitamin D has been shown to reduce fracture at non-vertebral sites, including the hip. Although ERT, SERMs and tibolone all retard bone loss, prospective fracture prevention has only been shown for SERMs and then only at the spine. Bisphosphonates represent a class of potent anti-resorptive agents, which have been shown to reduce fracture rate at vertebral and non-vertebral sites. Other agents such as calcitonin, PTH and fluoride are of less certain benefit in preventing fracture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:36:27