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Titolo:
Oestrogen and selective oestrogen receptor modulators (SERMs): current roles in the prevention and treatment of osteoporosis
Autore:
Albertazzi, P; Purdie, DW;
Indirizzi:
Hull Royal Infirm, Ctr Metab Bone Dis, Kingston Upon Hull HU3 2RW, N Humberside, England Hull Royal Infirm Kingston Upon Hull N Humberside England HU3 2RW England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 451 - 468
SICI:
1521-6942(200107)15:3<451:OASORM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; HORMONE REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; ESTROGEN-RECEPTOR; RANDOMIZED TRIAL; PLASMA ESTRADIOL; BREAST-CANCER; ELDERLY WOMEN; LUMBAR SPINE; RALOXIFENE;
Keywords:
oestrogen; HRT; raloxifene; SERMs; osteoporosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Purdie, DW Hull Royal Infirm, Ctr Metab Bone Dis, HS Brocklehurst Bldg,220-236 AnlabyRd, Kingston Upon Hull HU3 2RW, N Humberside, England Hull RoyalInfirm HS Brocklehurst Bldg,220-236 Anlaby Rd Kingston Upon Hull N Humberside England HU3 2RW
Citazione:
P. Albertazzi e D.W. Purdie, "Oestrogen and selective oestrogen receptor modulators (SERMs): current roles in the prevention and treatment of osteoporosis", BEST PR R C, 15(3), 2001, pp. 451-468

Abstract

Post-menopausal oestrogen replacement therapy (HRT) is the agent of choicefor restraint of post-menopausal bone loss. In numerous observational, andin a few intervention studies, it has been shown to reduce osteoporotic fractures. However, in order to be effective treatment has to be carried on long term. This is a task not easily achieved due to poor patient adherence. The majority of patients stop treatment after a few months. Fear of breastcancer and refusal to tolerate resumption of cyclic withdrawal bleeding are the principal objections. Newer and more user-friendly forms of treatmentare needed. Ideally, these should have an efficacy similar to oestrogen onthe central nervous system, cardiovascular system and bone, without adverse effects on the breast and uterus. With this in mind, Selective oestrogen Receptor Modulators (SERMs) have been developed. In this chapter we review how effective modern pharmacology has been in achieving an improved design of hormonal replacement for the post-menopausal women, and the place that it has obtained today alongside both older and newer forms of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:30:50