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Titolo:
The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak
Autore:
Karlsson, M; Bass, S; Seeman, E;
Indirizzi:
Malmo Univ Hosp, Dept Orthopaed, SE-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden SE-20502 Orthopaed, SE-20502 Malmo, Sweden Deakin Univ, Sch Hlth Sci, Melbourne, Vic, Australia Deakin Univ Melbourne Vic Australia Hlth Sci, Melbourne, Vic, Australia Univ Melbourne, Austin & Repatriat Med Ctr, Endocrine Unit, Dept Med, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia pt Med, Melbourne, Vic, Australia
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 429 - 450
SICI:
1521-6942(200107)15:3<429:TETEDG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; RANDOMIZED CONTROLLED TRIAL; WEIGHT-BEARING EXERCISE; ESTIMATED MECHANICAL CHARACTERISTICS; RESISTANCE TRAINING-PROGRAM; NURSING-HOME RESIDENTS; PHYSICAL-ACTIVITY; HIP FRACTURE; POSTMENOPAUSAL WOMEN; MUSCLE STRENGTH;
Keywords:
muscle strength; muscle mass; bone mass; bone structure; falls; injurious falls; fragility fractures; fracture prevention;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Karlsson, M Malmo Univ Hosp, Dept Orthopaed, SE-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden SE-20502 SE-20502 Malmo, Sweden
Citazione:
M. Karlsson et al., "The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak", BEST PR R C, 15(3), 2001, pp. 429-450

Abstract

There has never been, and will never be, a randomized double-blind placebo-controlled trial demonstrating that exercise in youth, adulthood or old age reduces fragility or osteoporosis-related fractures in old age. The next level of evidence, a randomized, controlled but unblinded study with fractures as an end-point is feasible but has never been done. The basis for the belief that exercise reduces fractures is derived from lower levels of 'evidence', namely, retrospective and prospective observation cohort studies and case-control studies. These studies are at best hypothesis generating, never hypothesis testing. They are all subject to many systematic biases and should be interpreted with extreme scepticism. Surrogate measures of anti-fracture efficacy are the next level of evidence, such as the demonstration of a reduction in risk factors for falls, a reduction in falls, a reductionin fractures due to falls, an increase in peak bone size and mass, prevention of bone loss in midlife and restoration of bone mass and structure in old age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 01:00:34