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Titolo:
Aetiopathogenesis of primary sclerosing cholangitis
Autore:
Cullen, S; Chapman, R;
Indirizzi:
Oxford Radcliffe Hosp, Dept Gastroenterol, Oxford, England Oxford Radcliffe Hosp Oxford England ept Gastroenterol, Oxford, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 577 - 589
SICI:
1521-6918(200108)15:4<577:AOPSC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; RAPID DISEASE PROGRESSION; PRIMARY BILIARY-CIRRHOSIS; BASEMENT-MEMBRANE MATRIX; NORMAL RAT-LIVER; BILE-DUCT CELLS; ULCERATIVE-COLITIS; T-CELLS; CLINICAL PRESENTATION; SERUM AUTOANTIBODIES;
Keywords:
primary sclerosing cholangitis; pathogenesis; immunogenetic; bacteria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Cullen, S Oxford Radcliffe Hosp, Dept Gastroenterol, Oxford, England Oxford Radcliffe Hosp Oxford England enterol, Oxford, England
Citazione:
S. Cullen e R. Chapman, "Aetiopathogenesis of primary sclerosing cholangitis", BEST PR RES, 15(4), 2001, pp. 577-589

Abstract

The aetiology and pathogenesis of PSC have not yet been clearly defined. The hypothesis that PSC is an immune mediated disease is supported by associations with HLA haplotypes, the presence of autoantibodies, increased levels of total serum immunoglobulins and the association with other autoimmune diseases. PSC does not, however, have many of the characteristics of classical autoimmunity, particularly the usual female preponderance of disease and lack of a good response to immunosuppression. Non-immune mechanisms such as bacterial infection, ischaemia and toxicity are also clearly important in the development of the disease and these factors may trigger peribiliary inflammation and cytokine-induced hepatic fibrosis. PSC may be triggered ingenetically susceptible individuals by toxic or infectious agents gaining access to the liver via a diseased and permeable colon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:07:29