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Titolo:
INFLAMMATORY BOWEL-DISEASE - AN IMMUNITY-MEDIATED CONDITION TRIGGEREDBY BACTERIAL-INFECTION WITH HELICOBACTER-HEPATICUS
Autore:
CAHILL RJ; FOLTZ CJ; FOX JG; DANGLER CA; POWRIE F; SCHAUER DB;
Indirizzi:
MIT,DIV COMPARAT MED,ROOM 56-787B,77 MASSACHUSETTS AVE CAMBRIDGE MA 02139 MIT,DIV COMPARAT MED CAMBRIDGE MA 02139 MIT,DIV TOXICOL CAMBRIDGE MA 02139 DNAX RES INST MOL & CELLULAR BIOL INC PALO ALTO CA 94301
Titolo Testata:
Infection and immunity
fascicolo: 8, volume: 65, anno: 1997,
pagine: 3126 - 3131
SICI:
0019-9567(1997)65:8<3126:IB-AIC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; HOMOSEXUAL MEN; SCID MICE; SP-NOV; GASTROENTERITIS; COLITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Cahill et al., "INFLAMMATORY BOWEL-DISEASE - AN IMMUNITY-MEDIATED CONDITION TRIGGEREDBY BACTERIAL-INFECTION WITH HELICOBACTER-HEPATICUS", Infection and immunity, 65(8), 1997, pp. 3126-3131

Abstract

Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response to enteric flora or a normal immunological response to a specific pathogen, No study to date has combined both factors, The present studies were carried out with an immunologically manipulated mouse model of IBD, Mice homozygous for the severe combined immunodeficiency (scid) mutation develop IBD with adoptive transfer of CD4(+) T cells expressing high levels of CD45RB (CD45RB(high) CD4(+) T cells), These mice do not develop IBD in germfree conditions, implicating undefined intestinal flora in the pathogenesis of lesions, In controlled duplicate studies, the influence of a single murine pathogen, Helicobacter hepaticus, in combination with the abnormal immunological response on the development of IBD was assessed, The combination of H. hepaticus infection and CD45RB(high) CD4(+) T-cell reconstitution resulted in severe disease expression similar to that observed in human IBD, This study demonstrates that IBD develops in mice as a consequence of an abnormal immune response in the presence of a single murine pathogen, H, hepaticus. The interaction of host immunity and a single pathogen in this murine system provides a novel model of human IBD, an immunity-mediated condition triggered by bacterial infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:51:54