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Titolo:
Prognostic factors and outcome of thymectomy in 80 cases of myasthenia gravis
Autore:
Vazquez-Pelillo, JC; Alonso, JLG; Diaz-Agero, P; Sanchez-Giron, JG; Serrano, RR; Tejedor, ED; Pajuelo, MC;
Indirizzi:
Hosp Univ La Paz, Serv Neurol, Madrid, Spain Hosp Univ La Paz Madrid Spain p Univ La Paz, Serv Neurol, Madrid, Spain Hosp Univ La Paz, Serv Cirugia Torac, Madrid, Spain Hosp Univ La Paz Madrid Spain La Paz, Serv Cirugia Torac, Madrid, Spain
Titolo Testata:
ARCHIVOS DE BRONCONEUMOLOGIA
fascicolo: 4, volume: 37, anno: 2001,
pagine: 166 - 170
SICI:
0300-2896(200104)37:4<166:PFAOOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
SPA
Soggetto:
EXTENDED THYMECTOMY;
Keywords:
myasthenia gravis; thymectomy; prognostic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Vazquez-Pelillo, JC Camarena 130 5 4, Madrid 28047, Spain Camarena 130 5 4 Madrid Spain 28047 rid 28047, Spain
Citazione:
J.C. Vazquez-Pelillo et al., "Prognostic factors and outcome of thymectomy in 80 cases of myasthenia gravis", ARCH BRONCO, 37(4), 2001, pp. 166-170

Abstract

Objectives: To analyze the results of thymectomy in our series of patientswith myasthenia gravis (MG) and to study the influence of the most common prognostic factors. Material and methods: Eighty MG patients over a period of 23 years underwent thymectomy consecutively in our hospital. Preoperative assessment included clinical evaluation of muscle weakness, edrophonium testing, electromyography, lung function testing, chest X-rays and CAT scans. Symptoms were assessed by the Osserman scale. The surgical approach was amplified transsternal thymectomy. The prognostic factors studied were sex, age, clinical stage, duration of disease before surgery and histology of the thymus. Clinical outcome was assessed using Millichap and Dodge's criteria. Follow-up was bythe chest surgery and neurology departments. Results: Complete remission was observed in 29 cases (36.2%) and significant improvement in 42 (52.5%). Complications developed in 9 patients (11.2%). Most patients were women (53/27) and outcomes for men and women were not statistically different. Mean age was 36 years (range 11-79), with no significant difference in outcome for patients who were older or younger than 60years of age. Nor were differences evident related to presurgical clinicalstage or levels of severity (I + IIa/IIb + III). Differences in outcome were highly significantly related to duration of disease (<24/>24 months) (p=0.0022), such that outcome was more satisfactory when the pre-surgical course of disease was shorter, provided that no thymoma was present. Conclusions: Amplified transsternal thymectomy was safe and effective for those patients with MG. When disease had been present for less than two years, the prognosis was better.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:50:43