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Titolo:
Neural correlates of formal thought disorder in schizophrenia - Preliminary findings from a functional magnetic resonance imaging study
Autore:
Kircher, TTJ; Liddle, PF; Brammer, MJ; Williams, SCR; Murray, RM; McGuire, PK;
Indirizzi:
Univ Tubingen, Dept Psychiat, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 ychiat, D-72076 Tubingen, Germany Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada GKT Sch Med, London, England GKT Sch Med London EnglandGKT Sch Med, London, England Inst Psychiat, Neuroimaging Res Unit, London, England Inst Psychiat London England at, Neuroimaging Res Unit, London, England Inst Psychiat, Dept Biostat & Comp, London, England Inst Psychiat LondonEngland hiat, Dept Biostat & Comp, London, England Inst Psychiat, Div Psychol Med, London, England Inst Psychiat London England Psychiat, Div Psychol Med, London, England Inst Psychiat, Sect Neuroimaging, London, England Inst Psychiat London England ychiat, Sect Neuroimaging, London, England
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 8, volume: 58, anno: 2001,
pagine: 769 - 774
SICI:
0003-990X(200108)58:8<769:NCOFTD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERIC BRAIN ACTIVATION; CEREBRAL BLOOD-FLOW; LEFT TEMPORAL-LOBE; PLANUM TEMPORALE; FMRI; TOMOGRAPHY; DIAGNOSIS; ASYMMETRY; SYMPTOMS; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kircher, TTJ Univ Tubingen, Dept Psychiat, Osianderstr 24, D-72076 Tubingen, Germany Univ Tubingen Osianderstr 24 Tubingen Germany D-72076 ermany
Citazione:
T.T.J. Kircher et al., "Neural correlates of formal thought disorder in schizophrenia - Preliminary findings from a functional magnetic resonance imaging study", ARCH G PSYC, 58(8), 2001, pp. 769-774

Abstract

Background: Formal thought disorder (FTD) is a core symptom of schizophrenia, but its pathophysiology is little understood. We examined the neural correlates of FTD using functional magnetic resonance imaging. Methods: Blood oxygenation level-dependent contrast was measured using functional magnetic resonance imaging while 6 patients with schizophrenia and 6 control subjects spoke about 7 Rorschach inkblots for 3 minutes each. In patients, varying degrees of thought-disordered speech were elicited duringeach "run. " In a within-subject design, the severity of positive FTD was correlated with the level of blood oxygenation level-dependent contrast in the 2 runs that showed the highest variance of FTD in each patient. Results: The severity of positive FTD in patients was negatively correlated (P < .001) with signal changes in the left superior and middle temporal gyri. Positive correlations were evident in the cerebellar vermis, the rightcaudate body, and the precentral gyrus. Conclusions: The severity of positive FTD was inversely correlated with the level of activity in the Wernicke area, a region implicated in the production of coherent speech. Reduced activity in this area might contribute to the articulation of incoherent speech. Because of the small sample size, these findings should be considered preliminary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:27:18