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Titolo:
Acute viral lymphadenitis mimicking low-grade peripheral T-cell lymphoma -A clinicopathological study of nine cases
Autore:
Kojima, M; Nakamura, S; Itoh, H; Yoshida, K; Suchi, T; Masawa, N;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210923, Japan Dokkyo Univ Mibu Tochigi Japan 3210923 ol 1, Mibu, Tochigi 3210923, Japan Aichi Canc Ctr Hosp, Dept Pathol & Genet, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 enet, Nagoya, Aichi 464, Japan Maebashi Red Cross Hosp, Dept Pathol & Clin Labs, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan abs, Maebashi, Gumma, Japan Kiryu Welf Gen Hosp, Dept Pathol & Clin Labs, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp Kiryu Gumma Japan l & Clin Labs, Kiryu, Gumma, Japan
Titolo Testata:
APMIS
fascicolo: 6, volume: 109, anno: 2001,
pagine: 419 - 427
SICI:
0903-4641(200106)109:6<419:AVLMLP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; HYPERPLASTIC GERMINAL-CENTERS; INFECTIOUS-MONONUCLEOSIS; INSITU HYBRIDIZATION; ANGIOIMMUNOBLASTIC LYMPHOMA; EXPRESSION; IMMUNOHISTOCHEMISTRY; LYMPHADENOPATHY; HISTOPATHOLOGY; HETEROGENEITY;
Keywords:
viral lymphadenitis; angioimmunoblastic T-cell lymphoma; T-zone lymphoma; Epstein-Barr virus; follicular hyperplasia; monocytoid B-cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210923, Japan Dokkyo Univ Mibu Tochigi Japan 3210923 , Tochigi 3210923, Japan
Citazione:
M. Kojima et al., "Acute viral lymphadenitis mimicking low-grade peripheral T-cell lymphoma -A clinicopathological study of nine cases", APMIS, 109(6), 2001, pp. 419-427

Abstract

Acute viral lymphadenitis, especially infectious mononucleosis (IM), oftenshows the presence of Reed-Sternberg-like cells, resulting in confusion with Hodgkin's disease. However, acute viral lymphadenitis requiring differential diagnosis from non-Hodgkin's lymphoma is not widely recognized. We describe the clinicopathological and immunohistochemical features of lymph node lesions from nine such patients which pose serious problems of differential diagnosis from low-grade peripheral T-cell lymphoma. There were three males and six females with ages ranging from 21 to 44 years (median 25 years). All patients had "B" symptoms and multicentric lymphadenopathy. The clinical course was also self-limiting. Each lymph node specimen showed an obvious expansion of an interfollicular area by pleomorphic and polymorphous infiltration with an increased number of arborizing postcapillary venules. Theinfiltrate was composed of variable numbers of small and medium-sized lymphocytes, immunoblasts, plasma cells in various stage of maturation and occasional granulocytes. The small lymphocytes usually had regular round nuclei, whereas the medium-sized lymphocytes occasionally showed nuclear pleomorphism. Hyperreactivity of B-lymphocytes, including hyperplastic germinal centers and/or foci of monocytoid B-cells, was seen in parts of the lesion. The majority of the interfollicular T-lymphocytes, including T-immunoblasts, expressed CD8 antigen. Various numbers of TIA-1-positive small and medium-sized T-cells were observed in the paracortical area. Despite these findings, the overall histological picture of this series posed serious difficulties when differentially diagnosing this condition from low-grade peripheral T-cell lymphomas such as angioimmunoblastic T-cell (AILD) and T-zone types, indicating that viral lymphadenitis occasionally presents with histologicalfeatures of AILD and T-zone lymphomas. To avoid overdiagnosis and overtreatment, we emphasize the need to pay careful attention to the clinical and laboratory findings as well as the morphological features.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:13:38