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Titolo:
Overexpression of peroxiredoxin in human breast cancer
Autore:
Noh, DY; Ahn, SJ; Lee, RA; Kim, SW; Park, IA; Chae, HZ;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Surg, Jungno Ku, Seoul 110744, South KoreaSeoul Natl Univ Seoul South Korea 110744 o Ku, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Pathol, Jungno Ku, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Ku, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Inst Canc Res, Lab Breast Canc Biol,Jongno Ku, Seoul, South Korea Seoul Natl Univ Seoul South Korea nc Biol,Jongno Ku, Seoul, South Korea Chonnam Natl Univ, Coll Nat Sci, Dept Biol, Kwangju 500757, South Korea Chonnam Natl Univ Kwangju South Korea 500757 Kwangju 500757, South Korea
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3B, volume: 21, anno: 2001,
pagine: 2085 - 2090
SICI:
0250-7005(200105/06)21:3B<2085:OOPIHB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PEROXIDE REDUCTASE; THIOREDOXIN PEROXIDASE; SACCHAROMYCES-CEREVISIAE; MAMMALIAN PEROXIREDOXIN; HYDROGEN-PEROXIDE; GENE; APOPTOSIS; IDENTIFICATION; ACTIVATION; MECHANISM;
Keywords:
peroxiredoxin; breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Noh, DY Seoul Natl Univ, Coll Med, Dept Surg, Jungno Ku, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 uth Korea
Citazione:
D.Y. Noh et al., "Overexpression of peroxiredoxin in human breast cancer", ANTICANC R, 21(3B), 2001, pp. 2085-2090

Abstract

The peroxiredoxins (Prx) are a family of 25kDa peroxidases that can reduceH2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Prx family is divided into six groups (Prx I-VI) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. Previous reports have shown that Prx II has proliferative and anti-apoptotic properties and thus may induce carcinogenic changes. We conducted this study to reveal the change in expression ofPrx in human breast cancer in comparison to normal tissues. Western immunoblotting using Prx type I, II and III antibodies was undertaken on 24 humanbreast cancer tissues and normal counterparts. We used antibodies against purified recombinant NKEF-A/PAG, NKEF-B and MER 5 which are the Prx isoforms. Type I Pix was overexpressed in the cancer tissues of 21 patients (87.5%), type II in 18 patients (75%) and type III in 19 patients (79.2%) in relation to normal tissue. However; no significant relationship was found between Pix overexpression and clinicopathological parameters of breast cancer such as tumor size, lymphatic invasiveness, hormone receptor status or nuclear and histologic grade. In conclusion, Prx is overexpressed in breast cancer tissues to a great extent suggesting that Prx has a proliferative effectand may be related to cancer development or progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:40:00