Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models
Autore:
Burger, AM; Mengs, U; Schuler, JB; Fiebig, HH;
Indirizzi:
Madaus AG, D-51109 Cologne, Germany Madaus AG Cologne Germany D-51109Madaus AG, D-51109 Cologne, Germany Univ Freiburg, Tumor Biol Ctr, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 ol Ctr, D-79106 Freiburg, Germany
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3B, volume: 21, anno: 2001,
pagine: 1965 - 1968
SICI:
0250-7005(200105/06)21:3B<1965:AAOAAM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-SPECIFIC LECTIN; VISCUM-ALBUM; A-CHAIN; APOPTOSIS; CELLS; CYTOTOXICITY; INDUCTION; CYTOKINES;
Keywords:
aqueous mistletoe extract; mistletoe lectin; anticancer activity; transplantable; syngeneic murine tumors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Mengs, U Madaus AG, Ostmerheimer Str 198, D-51109 Cologne, Germany Madaus AG Ostmerheimer Str 198 Cologne Germany D-51109 , Germany
Citazione:
A.M. Burger et al., "Anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models", ANTICANC R, 21(3B), 2001, pp. 1965-1968

Abstract

Mistletoe extracts have been used for decades for nonspecific stimulation of the immune system in cancer therapy. Mistletoe lectins (ML) have been identified as the active principle with cytotoxic and immunomodulatory potencies. In the present in viva experiments, the anticancer effects of an aqueous mistletoe extract (AME) were investigated in different subcutaneously growing syngeneic murine tumors such as Renca renal cell carcinoma, C8 colon 38 carcinoma, F9 testicular carcinoma, B16 melanoma and Lewis lung carcinoma. The animals used were immunocompetent mice of different strains (C57BL/6, BALB/c), depending on the type of tumor tested. After tumor transplantation, the mice were treated with AME at dose levels corresponding to 0, 0.3, 3, 30 or 300 ng ML/kg/d by the i.p. or s.c. route for a maximum of 4 consecutive weeks. The tumor volume was determined by serial caliper measurementsand expressed relative to controls. Significant tumor growth inhibition was observed with the Renca, C8 colon 38 and F9 testicular carcinomas at 30 and 300 ng ML/kg/d. These findings were confirmed in independent repeat experiments. No inhibitory effects were seen with the Lewis lung carcinoma and B16 melanoma under the conditions described above. In conclusion, AME showed in vivo anticancer activity in different transplantable syngeneic murine tumor models following repeated parenteral treatment. In view of the low dose levels used, the effects are most likely due to the immunostimulatory rather than to the cytotoxic potencies of AME.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:36:41