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Titolo:
Efficacy of single-bolus vs. frequent low-dose treatment with nitrosourea in experimental gliomas
Autore:
Wu, CM; Inamura, T; Ikezaki, K; Nakamizo, A; Inoha, S; Yaosaka, F; Fukui, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Neurosurg, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 ed Sci, Dept Neurosurg, Fukuoka 812, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3B, volume: 21, anno: 2001,
pagine: 1835 - 1838
SICI:
0250-7005(200105/06)21:3B<1835:EOSVFL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS-INFUSION CISPLATIN; RAT-BRAIN TUMOR; INTRACAROTID INFUSION; BRADYKININ ANALOG; GASTRIC-CANCER; PHASE-II; CHEMOTHERAPY; 5-FLUOROURACIL; CARBOPLATIN; RADIATION;
Keywords:
bolus treatment; C6 glioma; chemotherapy; frequent low-dose treatment; nitrosourea; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Inamura, T 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan 3-1-1 Maidashi,Higashi Ku Fukuoka Japan 8128582 128582, Japan
Citazione:
C.M. Wu et al., "Efficacy of single-bolus vs. frequent low-dose treatment with nitrosourea in experimental gliomas", ANTICANC R, 21(3B), 2001, pp. 1835-1838

Abstract

Background: Malignant glioma remains a fatal disease. Continuous or frequent low-dose (FLD) chemotherapy with nitrosoureas reportedly causes fewer side-effects than single-bolus therapy without decreasing the antitumour effects. Materials and Methods: To study the effect of FLD treatment with nimustine (ACNU) in rats with glioma, we intracerebrally inoculated with C6 glioma cells. We began the ACNU treatment 5 or 8 days later (total dose, 25 or 40 mg/kg) i.p. as either one bolus or smaller doses spread over 5 days week. Results: At a total dose of 25 mg/kg beginning at day 8, survival duration did not differ between untreated controls and the FLD group, while the bolus significantly prolonged survival; the FLD group showed some improvementbeyond control survival at 40 mg/kg (each p < 0.001). Beginning treatment after 5 rather than 8 days prolonged survival somewhat further. Conclusion:FLD treatment with ACNU is less effective against experimental glioma in rats than bolus treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:34:13