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Titolo:
Electrically mediated drug delivery for treatment of an adenocarcinoma transplanted into rat liver
Autore:
Engstrom, PE; Ivarsson, K; Tranberg, KG; Stenram, U; Salford, LG; Persson, BRR;
Indirizzi:
Univ Lund Hosp, Dept Radiat Phys, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 t Radiat Phys, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Surg, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 sp, Dept Surg, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Pathol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 , Dept Pathol, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Neurosurg, Rausing Lab, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 , Rausing Lab, SE-22185 Lund, Sweden
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3B, volume: 21, anno: 2001,
pagine: 1817 - 1822
SICI:
0250-7005(200105/06)21:3B<1817:EMDDFT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; MALIGNANT-TUMORS; ELECTROCHEMOTHERAPY; METASTASES; BLEOMYCIN; MODEL; PEROXIDATION; EXPERIENCE; CARCINOMA; RESECTION;
Keywords:
liver; tumour; rat; adenocarcinoma; electrochemotherapy; electroporation; ETC; lymphocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Persson, BRR Univ Lund Hosp, Dept Radiat Phys, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 , SE-22185 Lund, Sweden
Citazione:
P.E. Engstrom et al., "Electrically mediated drug delivery for treatment of an adenocarcinoma transplanted into rat liver", ANTICANC R, 21(3B), 2001, pp. 1817-1822

Abstract

Background: In this study, electrochemotherapy (ECT), i.e. tumour treatment based on local augmentation of intracellular drug delivery from short, intense electric pulses, was evaluated in rats with an adenocarcinoma implanted into the liver. Tumour response and concentrations of macrophages and T-lymphocytes (CD4 and CD8) in and around the tumour were measured. Materialsand Methods: Rats were treated with permeabilizing electric pulses, bleomycin, or both, eight days after implantation of the tumour, while one group received sham treatment. Results: Treatment with electric pulses and bleomycin resulted in a significantly reduced lesion volume and 92% cure rate (12out of 13, p < 0.0002 compared to the other treatment groups). The highestconcentration of CD8 lymphocytes was found in tumours treated with electric pulses and bleomycin. Macrophages were found mainly in tumours treated with electric pulses, with or without bleomycin. Conclusion: Electrochemotherapy using millisecond exponential pulses and bleomycin is efficient in a rat liver tumour model and appears to stimulate the host's immune system.

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Documento generato il 04/07/20 alle ore 12:08:47