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Titolo:
Prognostic value of beta 1-integrin (=CD29) in serous adenocarcinomas of the ovary
Autore:
Muller-Klingspor, V; Hefler, L; Obermair, A; Kaider, A; Breitenecker, G; Leodolter, S; Kohlberger, P;
Indirizzi:
Univ Vienna, Sch Med, Dept Obstet & Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 stet & Gynecol, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Med Comp Sci Clin Biometr, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 i Clin Biometr, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Clin Pathol, Gynecopathol Unit, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 ecopathol Unit, A-1090 Vienna, Austria
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 3C, volume: 21, anno: 2001,
pagine: 2185 - 2188
SICI:
0250-7005(200105/06)21:3C<2185:PVOB1(>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; BETA-1 INTEGRINS; CARCINOMA; EXPRESSION;
Keywords:
beta 1-integrin; immunohistochemistry; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kohlberger, P Univ Vienna, Sch Med, Dept Obstet & Gynecol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
V. Muller-Klingspor et al., "Prognostic value of beta 1-integrin (=CD29) in serous adenocarcinomas of the ovary", ANTICANC R, 21(3C), 2001, pp. 2185-2188

Abstract

Background: Integrins are heterodimeric transmembranous proteins, comprised of two transmembrane subunits, called alpha and beta. They bind to various structures of the extra cellular matrix (ECM) and are responsible for cell-cell interactions. The aim of the current study was to evaluate the prognostic value of beta1-integrin in patients suffering from malignant serous surface epithelial-stromal tumors of the ovary. Materials and Methods: With immunohistochemical methods we investigated 76 formalin-fixed, paraffin-embedded tissue samples. FIGO stages I, II, III and IV were present in 18, 10,41 and 7 cases, respectively. Results: 12 sections (15.8%) stained positive for beta1-integrin (= CD29), 64 sections (84.2%) showed no expression of beta1-integrin. The product limit method by Kaplan and Meier showed no statistical significance of beta1-integrin expression on overall survival. (p =0.1005, log-rank test). Also the univariate Cox regression analysis showedno statistical significance of beta1-integrin expression on overall survival (p = 0.1066), whereas in the multivatiate analysis, adjusted for grading, FIGO stage and residual tumor, the expression of beta1-integrin turned out to be significantly correlated with reduced overall survival (p=0.0208). Conclusion: Our results using multivariate Cox regression analysis indicated a shorter overall survival for patients with positive staining for beta1-integrin in malignant serous surface epithelial-stromal tumors of the ovary. This pilot study warrants further investigation of the role of beta1-integrin in ovarian cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:21:55