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Titolo:
The effect of trimetazidine on the survival of rat island skin flaps subjected to ischemia-reperfusion injury
Autore:
Kara, IG; Kara, CO; Ozden, A; Ocsel, H;
Indirizzi:
Pamukkale Univ, Fac Med, Dept Plast & Reconstruct Surg, Denizli, Turkey Pamukkale Univ Denizli Turkey Plast & Reconstruct Surg, Denizli, Turkey Pamukkale Univ, Fac Med, Dept Otorhinolaryngol, Denizli, Turkey Pamukkale Univ Denizli Turkey d, Dept Otorhinolaryngol, Denizli, Turkey Pamukkale Univ, Fac Med, Dept Gen Surg, Denizli, Turkey Pamukkale Univ Denizli Turkey , Fac Med, Dept Gen Surg, Denizli, Turkey
Titolo Testata:
ANNALS OF PLASTIC SURGERY
fascicolo: 2, volume: 47, anno: 2001,
pagine: 168 - 171
SICI:
0148-7043(200108)47:2<168:TEOTOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-FREE RADICALS; NO-REFLOW PHENOMENON; SUPEROXIDE-DISMUTASE; RENAL ISCHEMIA; NEUTROPHILS; ALLOPURINOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kara, IG Pamukkale Univ, Fac Med, Dept Plast & Reconstruct Surg, Denizli, Turkey Pamukkale Univ Denizli Turkey econstruct Surg, Denizli, Turkey
Citazione:
I.G. Kara et al., "The effect of trimetazidine on the survival of rat island skin flaps subjected to ischemia-reperfusion injury", ANN PL SURG, 47(2), 2001, pp. 168-171

Abstract

The effect of trimetazidine (TMZ) on flap ischemia-reperfusion injury was investigated in rat inferior epigastric artery flaps. Twenty-six rats, divided into four experimental groups-nonischemic group (group 1, N = 5), ischemic control group (group 2, N = 7), preischemic TMZ-treated group (group 3,N = 7), and postischemic TMZ-treated group (group 4, N = 7)-were used. Ratinferior epigastric artery flaps were rendered ischemic by occluding the feeding femoral artery, and they were reperfused by releasing the clamps after 11 hours in groups 2 through 4. Group 3 rats were given TMZ (3 mg per kilogram, intravenously) diluted in saline before application of the clamp, and group 4 rats were given TMZ before clamp removal. Flap survival was scored on postoperative day 8. All flaps in the nonischemic control group (group 1) survived completely. The ischemic control group (group 2) demonstrateda 6.3 +/- 4.3% survival area. In the preischemic TMZ group (group 3) the mean survival area was 76.9 +/- 6.1%, and in the postischemic TMZ group (group 4) it was 76.8 +/- 5.6%. TMZ-treated flaps showed a significant increasein survival area regardless of the time of administration (p = 0.001, group 3 vs. group 2; p = 0.001, group 4 vs. group 2). This finding suggests that TMZ has a beneficial effect on the prevention or treatment of arterial ischemic flaps.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:48:34