Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Technetium-99m-sestamibi scintigraphy: an alternative approach for diagnosis and follow-up of active myeloma lesions after high-dose chemotherapy andautologous stem cell transplantation
Autore:
Svaldi, M; Tappa, C; Gebert, U; Bettini, D; Fabris, P; Franzelin, F; Osele, L; Mitterer, M;
Indirizzi:
Reg Hosp, Dept Haematol, I-39100 Bolzano, Italy Reg Hosp Bolzano Italy I-39100 sp, Dept Haematol, I-39100 Bolzano, Italy Reg Hosp, Bone Marrow Transplantat Ctr, I-39100 Bolzano, Italy Reg Hosp Bolzano Italy I-39100 Transplantat Ctr, I-39100 Bolzano, Italy Reg Hosp, Dept Nucl Med, I-39100 Bolzano, Italy Reg Hosp Bolzano Italy I-39100 sp, Dept Nucl Med, I-39100 Bolzano, Italy Reg Hosp, Dept Radiol, I-39100 Bolzano, Italy Reg Hosp Bolzano Italy I-39100 Hosp, Dept Radiol, I-39100 Bolzano, Italy
Titolo Testata:
ANNALS OF HEMATOLOGY
fascicolo: 7, volume: 80, anno: 2001,
pagine: 393 - 397
SICI:
0939-5555(200107)80:7<393:TSAAAF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-MYELOMA; BONE-MARROW; PROGNOSTIC VALUE; STAGING SYSTEM; MICROGLOBULIN;
Keywords:
methoxy isobutyl isonitrile (MIBI); multiple myeloma; conventional radiographs; monoclonal gammopathy of unknown significance (MGUS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mitterer, M Reg Hosp, Dept Haematol, L Bohlerstr 5, I-39100 Bolzano, ItalyReg Hosp L Bohlerstr 5 Bolzano Italy I-39100 0 Bolzano, Italy
Citazione:
M. Svaldi et al., "Technetium-99m-sestamibi scintigraphy: an alternative approach for diagnosis and follow-up of active myeloma lesions after high-dose chemotherapy andautologous stem cell transplantation", ANN HEMATOL, 80(7), 2001, pp. 393-397

Abstract

Technetium-99m-sestamibi (MIBI) is a radionuclide tracer taken up by different malignant tumors. A total of 88 MIBI scans were carried out in 20 individuals with monoclonal gammopathy of unknown significance (MGUS) and 10 patients during follow-up for other cancers. Of these 58 MIBI scans were carried out in 46 myeloma patients: 15 at diagnosis, 14 during conventional chemotherapy, and 29 following high-dose sequential therapy and autologous peripheral blood progenitor support. A positive MIBI scan was exhibited by 1 of 10 with non-myeloma cancers and 2 of 20 with MGUS. In contrast, all stageII and III multiple myelomas (MM) were positive at diagnosis. Therefore, the sensitivity of the MIBI scan at diagnosis was 100%, whereas the specificity in this cohort was 93%. Four different MIBI patterns could be distinguished in MM patients: physiological, focal, diffuse, and extramedullary uptakes. In comparison to conventional skeletal radio,graphs, MIBI scans recognized a higher number of myeloma lesions at diagnosis. MIBI scans remained positive in all patients during conventional chemotherapy, and there was a direct correlation between MIBI result and clinical outcome of patients following high-dose therapy. Eighteen patients had a negative MIBI scan: 9 werein complete remission (CR), 8 in partial remission (PR), and I had progressive disease. Eleven patients showed lesions on the MIBI scan: 4 were in PR, 5 had progressive disease, 1 had a minimal response, and only 1 was in CR. A diffuse MIBI pattern reflected a higher bone marrow plasma cell number. In five patients, histologically or cytologically verified soft tissue myeloma lesions were correctly diagnosed by MIBI scan, while all plain radiographs showed none of them. MIBI has proven to be an effective tool in diagnosing biologically active myeloma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 08:57:09