Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Abnormal chromatographic patterns of porphyrins in urine
Autore:
Nuttall, KL;
Indirizzi:
Childrens & Womens Hlth Ctr, Dept Pathol & Lab Med, Vancouver, BC V6H 3N1,Canada Childrens & Womens Hlth Ctr Vancouver BC Canada V6H 3N1 BC V6H 3N1,Canada
Titolo Testata:
ANNALS OF CLINICAL AND LABORATORY SCIENCE
fascicolo: 3, volume: 31, anno: 2001,
pagine: 259 - 264
SICI:
0091-7370(200107)31:3<259:ACPOPI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
porphyrins; porphyria cutanea tarda; photosensitivity; porphobilinogen; HPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Nuttall, KL Childrens & Womens Hlth Ctr, Dept Pathol & Lab Med, Room 2J10,4500 Oak St,Vancouver, BC V6H 3N1, Canada Childrens & Womens Hlth Ctr Room 2J10,4500 Oak St Vancouver BC Canada V6H 3N1
Citazione:
K.L. Nuttall, "Abnormal chromatographic patterns of porphyrins in urine", ANN CLIN L, 31(3), 2001, pp. 259-264

Abstract

Urine is the most frequent specimen used in the initial evaluation of adult patients who present with photosensitivity. When urine porphyrins are abnormal, characterization of the chromatogram is facilitated by calculation of uroporphyrin-to-heptacarboxylate porphyrin (uro/hepta) and uroporphyrin-to-isocoproporphyrin (uro/iso) ratios. The most frequent abnormal pattern, and that most consistent with porphyria cutanea tarda (PCT), is an uro/heptaratio less than or equal to2.0 and an uro/iso ratio less than or equal to 18. When the uro/hepta or uro/iso ratios are less consistent with PCT, other less common porphyrin disorders should be considered. These include variegate porphyria, coproporphyria with manifestations of photosensitivity only, adult onset congenital porphyria, mixed porphyrias, and other less frequent porphyrin disorders. After initial evaluation, the diagnosis should ideally be confirmed by additional testing of blood and fecal specimens. Most attacks of the acute porphyrias are associated with a uro/hepta ratio >4, and can be confirmed by an elevated urine porphobilinogen concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:50:34