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Titolo:
Trace determination of fluoroquinolone antibacterial agents in solid-phaseextraction urban wastewater by and liquid chromatography with fluorescencedetection
Autore:
Golet, EM; Alder, AC; Hartmann, A; Ternes, TA; Giger, W;
Indirizzi:
EAWAG, CH-8600 Dubendorf, Switzerland EAWAG Dubendorf Switzerland CH-8600 AWAG, CH-8600 Dubendorf, Switzerland ETH Zurich, CH-8600 Dubendorf, Switzerland ETH Zurich Dubendorf Switzerland CH-8600 CH-8600 Dubendorf, Switzerland ESWE Inst Water Res & Water Technol, D-65201 Wiesbaden, Germany ESWE Inst Water Res & Water Technol Wiesbaden Germany D-65201 n, Germany
Titolo Testata:
ANALYTICAL CHEMISTRY
fascicolo: 15, volume: 73, anno: 2001,
pagine: 3632 - 3638
SICI:
0003-2700(20010801)73:15<3632:TDOFAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANDEM MASS-SPECTROMETRY; AQUATIC ENVIRONMENT; BIOLOGICAL SAMPLES; HUMAN-PLASMA; CIPROFLOXACIN; ANTIBIOTICS; CONFIRMATION; METABOLITES; URINE; PHARMACEUTICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Alder, AC EAWAG, CH-8600 Dubendorf, Switzerland EAWAG Dubendorf Switzerland CH-8600 600 Dubendorf, Switzerland
Citazione:
E.M. Golet et al., "Trace determination of fluoroquinolone antibacterial agents in solid-phaseextraction urban wastewater by and liquid chromatography with fluorescencedetection", ANALYT CHEM, 73(15), 2001, pp. 3632-3638

Abstract

Fluoroquinolones (FQs) are among the most important antibacterial agents (synthetic antibiotics) used in human and veterinary medicine. An analyticalmethod based on reversed-phase liquid chromatography with fluorescence detection was developed and validated for the simultaneous determination of nine FQs and the quinolone pipemidic acid in urban wastewater. Aqueous samples were extracted using mixed-phase cation-exchange disk cartridges that were subsequently eluted by ammonia solution in methanol. Recoveries were above 80% at an overall precision of better than 10%. Instrumental quantification limits varied between 150 and 450 pg injected. The presented method was successfully applied to quantify FQs in effluents of urban wastewater treatment plants. The two most abundant human-use FQs, ciprofloxacin and norfloxacin, occurred in primary and tertiary wastewater effluents at concentrations between 249 and 405 ng/L and from 45 to 120 ng/L, respectively. The identity of FQs in urban wastewater was confirmed by recording full fluorescence spectra and liquid chromatography directly coupled to tandem mass spectrometry. These results indicate that conventional environmental risk assessment overestimates FQ concentrations in surface waters by 1 to 2 orders of magnitude.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:16:49