Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains
Autore:
Wang, EY; Bowen, RA; Medina, G; Powers, AM; Kang, WL; Chandler, LM; Shope, RE; Weaver, SC;
Indirizzi:
Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Pathol, Galveston, TX 77555 USA Univ Texas, Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 , Ctr Trop Dis, Galveston, TX 77555 USA Colorado State Univ, Anim Reprod & Biotechnol Lab, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Lab, Ft Collins, CO 80523 USA
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 1, volume: 65, anno: 2001,
pagine: 64 - 69
SICI:
0002-9637(200107)65:1<64:VAVCO1>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCEPHALOMYELITIS VIRUS; NUCLEOTIDE-SEQUENCES; SOUTH-AMERICA; ALPHAVIRUSES; INFECTION; EMERGENCE; COMPLEX; EASTERN; REGION; TC-83;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Weaver, SC Univ Texas, Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd Galveston TX USA 77555 n, TX 77555 USA
Citazione:
E.Y. Wang et al., "Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains", AM J TROP M, 65(1), 2001, pp. 64-69

Abstract

Following a 19-year hiatus, Venezuelan equine encephalitis (VEE) reemergedin western Venezuela in December 1992. This outbreak is important in understanding VEE emergence because phylogenetic studies imply that sympatric, enzootic, subtype ID VEE viruses mutated to generate the epizootic/epidemic. Although the 1992-1993 strains belong to subtype IC, a serotype implicatedin extensive outbreaks during the 1960s and in 1995, relatively small numbers of human and equine cases occurred in 1992-1993. We, therefore, evaluated the pathogenicity of these Venezuelan enzootic ID and epizootic IC viruses to determine 1) if they exhibit phenotypes like those described previously for more distantly related enzootic and epizootic strains. and 2) if the1992-1993 outbreak was limited by the inability of these IC viruses to exploit equines as amplification hosts. All strains were virulent in mice and guinea pigs, but were benign for cotton rats, natural hosts of enzootic viruses. However, only the IC strains produced equine disease, with mean peak viremias of 10(5) suckling mouse 50% lethal doses per mL serum, and some titers exceeding 10(7). These viremias approximate those observed previously with VEE strains isolated during more extensive epizootics, suggesting thatefficient equine amplification did not limit the scope and duration of the1992-1993 outbreak. Enzootic ID virus infection protected all horses from challenge with epizootic strain P676, supporting the hypothesis that epizootics bypass regions of enzootic transmission due to natural immunization ofequines by enzootic VEE viruses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:58:37