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Titolo:
Effects of high-frequency oscillation on endogenous surfactant in an acutelung injury model
Autore:
Kerr, CL; Veldhuizen, RAW; Lewis, JF;
Indirizzi:
Univ Western Ontario, St Josephs Hlth Ctr, Lawson Res Inst, Dept Med, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, St Josephs Hlth Ctr, Lawson Res Inst, Dept Physiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 2, volume: 164, anno: 2001,
pagine: 237 - 242
SICI:
1073-449X(20010715)164:2<237:EOHOOE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; HYALINE-MEMBRANE DISEASE; END-EXPIRATORY PRESSURE; HIGH TIDAL VOLUME; CONVENTIONAL VENTILATION; MECHANICAL VENTILATION; PULMONARY-EDEMA; AIRWAY PRESSURE; METABOLISM; SUBFRACTIONS;
Keywords:
surfactant; mechanical ventilation; ARDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, JF Univ Western Ontario, St Josephs Hlth Ctr, Lawson Res Inst, DeptMed, 268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario 268Grosvenor St London ON Canada N6A 4V2 a
Citazione:
C.L. Kerr et al., "Effects of high-frequency oscillation on endogenous surfactant in an acutelung injury model", AM J R CRIT, 164(2), 2001, pp. 237-242

Abstract

This study evaluated the effects of high-frequency oscillation (HFO) and conventional mechanical ventilation (CMV) on gas exchange and the pulmonary surfactant system in an acute lung injury model. Following induction of lung injury with N-nitroso-n-methylurethane, adult rabbits were anesthetized and randomized to one of the following ventilatory strategies: HFO for 120 min, CMV for 120 min, HFO for 60 min, followed by CMV for 60 min, CMV for 60min followed by HFO for 60 min or CMV for 60 min. Separate animals were ventilated using CMV with a lower tidal volume and a positive end-expiratory pressure level that was increased throughout the experimental period. Oxygenation was significantly greater in animals ventilated with HFO compared with animals ventilated with CMV. The proportion of surfactant in large aggregate forms was significantly greater following ventilatory support with HFOcompared with CMV, Surfactant aggregate conversion was also significantly lower during HFO compared with CMV. We conclude that in our model of acute lung injury, HFO was a superior mode of ventilation and reduced the conversion of alveolar surfactant large aggregates into small aggregate forms, resulting in a greater percentage of large aggregate forms in the alveolar space.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:44:50