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Titolo:
Stability of Adderall in extemporaneously compounded oral liquids
Autore:
Justice, J; Kupiec, TC; Matthews, P; Cardona, P;
Indirizzi:
Shire Richwood Inc, Med Informat Serv, Florence, KY 41042 USA Shire Richwood Inc Florence KY USA 41042 mat Serv, Florence, KY 41042 USA Analyt Res Labs, Oklahoma City, OK USA Analyt Res Labs Oklahoma City OK USA lyt Res Labs, Oklahoma City, OK USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 15, volume: 58, anno: 2001,
pagine: 1418 - 1421
SICI:
1079-2082(20010801)58:15<1418:SOAIEC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; METHYLPHENIDATE; CHILDREN;
Keywords:
amphetamine aspartate; amphetamine sulfate; central nervous system stimulants; compounding; dextroamphetamine saccharate; dextroamphetamine sulfate; incompatibilities; stability; storage; suspending agents; suspensions; sweetening agents; syrups;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Justice, J Shire Richwood Inc, Med Informat Serv, 7900 Tanners Gate Dr, Florence, KY 41042 USA Shire Richwood Inc 7900 Tanners Gate Dr Florence KY USA 41042 A
Citazione:
J. Justice et al., "Stability of Adderall in extemporaneously compounded oral liquids", AM J HEAL S, 58(15), 2001, pp. 1418-1421

Abstract

The short-term stability of Adderall in three extemporaneously compounded oral liquids was studied. Three suspensions of Adderall 1 mg/mL were prepared from commercially available 10-mg Adderall tablets with Ora-Sweet, Ora-Plus, and a 1:1 mixture ofOra-Sweet and Ora-Plus. Each suspension was stored in the dark in a stability chamber at 25 degreesC and 60% relative humidity for 30 days. The stability of the active drug (a mixture of levoamphetamine and dextroamphetaminesalts) in each of the three vehicles was determined immediately after preparation and at 10, 20, and 30 days by using gas chromatography-mass spectrometry (GCMS). No significant changes in concentrations of-either amphetamine isomer occurred during the 30-day study period. Visual inspection of samples revealed no changes in color or odor. Extemporaneously compounded liquid oral formulations of Adderall 1 mg/mL in Ora-Sweet, Ora-Plus, or a 1:1 mixture of Ora-Sweet and Ora-Plus were stable for at least 30 days at 25 degreesC and 60% relative humidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:33:15