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Titolo:
Approaches to the preparation of enantiomerically pure (2R,2 ' R)-(+)-threo-methylphenidate hydrochloride
Autore:
Prashad, M;
Indirizzi:
Novartis Inst Biomed Res, E Hanover, NJ 07936 USA Novartis Inst Biomed Res E Hanover NJ USA 07936 , E Hanover, NJ 07936 USA
Titolo Testata:
ADVANCED SYNTHESIS & CATALYSIS
fascicolo: 5, volume: 343, anno: 2001,
pagine: 379 - 392
SICI:
1615-4150(200107)343:5<379:ATTPOE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
THREO-METHYLPHENIDATE; ENANTIOSELECTIVE SYNTHESIS; N-METHOXYCARBONYLPIPERIDINE; ASYMMETRIC-SYNTHESIS; CONVENIENT METHOD; (+/-)-THREO-METHYLPHENIDATE; PHARMACOLOGY; RESOLUTION; ANALOGS; BRAIN;
Keywords:
attention deficit hyperactivity disorder; enantioselective synthesis; enzymatic hydrolysis; (2R,2 ' R)-threo-methylphenidate; resolution; ritalin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Prashad, M Novartis Inst Biomed Res, 59 Route 10, E Hanover, NJ 07936 USA Novartis Inst Biomed Res 59 Route 10 E Hanover NJ USA 07936 USA
Citazione:
M. Prashad, "Approaches to the preparation of enantiomerically pure (2R,2 ' R)-(+)-threo-methylphenidate hydrochloride", ADV SYNTH C, 343(5), 2001, pp. 379-392

Abstract

Various approaches to the preparation or enantiomerically pure (2R,2'R)-(+)-threo-methylphenidate hydrochloride (1) are reviewed. These approaches include synthesis using enantiomerically pure precursors obtained by resolution, classical and enzyme-based resolution approaches, enantioselective synthesis approaches, and approaches based on enantioselective synthesis of (2S,2'R)-erythro-methylphenidate followed by epimerization at the 2-position.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:05:04