Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects and mechanisms of triacetylshikimic acid on platelet adhesion to neutrophils induced by thrombin and reperfusion after focal cerebral ischemia in rats
Autore:
Chong, ZZ; Xu, QP; Sun, JN;
Indirizzi:
Beijing Univ Tradit Chinese Med, Dept Pharmacol, Beijing 100029, Peoples RChina Beijing Univ Tradit Chinese Med Beijing Peoples R China 100029 es RChina
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 8, volume: 22, anno: 2001,
pagine: 679 - 684
SICI:
0253-9756(200108)22:8<679:EAMOTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE ACTIVATION; ARTERIAL INJURY; P-SELECTIN; ANGIOPLASTY; MODEL; ACCUMULATION; DISEASE; BRAIN; PIGS;
Keywords:
triacetylshikimic acid; brain ischemia; blood platelets; neutrophils; P-selectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, QP Beijing Univ Tradit Chinese Med, Dept Pharmacol, Beijing 100029, Peoples RChina Beijing Univ Tradit Chinese Med Beijing Peoples R China 100029 na
Citazione:
Z.Z. Chong et al., "Effects and mechanisms of triacetylshikimic acid on platelet adhesion to neutrophils induced by thrombin and reperfusion after focal cerebral ischemia in rats", ACT PHAR SI, 22(8), 2001, pp. 679-684

Abstract

AIM: To investigate the effect of triacetylshikimic acid (TSA) on the platelet adhesion to neutrophils and P-selectin expression on activated platelet membrane induced by thrombin and reperfusion after focal cerebral ischemia. METHODS: The platelet adhesion to neutrophils was evaluated by rosette assay, and P-selectin expression on platelet membrane was determined by flowcytometry. RESULTS: TSA 10 - 1000 mu mol/L markedly inhibited thrombin(0.4kU/L)-induced platelet adhesion to neutrophils. The platelet adhesion to neutrophils induced by a 21-h reperfusion after middle cerebral artery occlusion for 3 h was also inhibited in a dose-dependent manner by TSA 50 - 200 mg/kg given by ig immediately and at 60 min again after the onset of cerebral ischemia. TSA was also shown to decrease the P-selectin expression on platelet surface induced by thrombin in washed platelet and by adenosine diphosphate (ADP) 5 mu mol/L in whole blood. CONCLUSION: Reperfusion after cerebral ischemia and thrombin induced platelet adhesion to neutrophils, which could be reduced by TSA probably due to its inhibition of P-selectin expression on activated platelets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:56:12