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Titolo:
Expression of cyclin-dependent kinase inhibitors, p21(cip1) and p27(kip1),during wound healing in rats
Autore:
Zhu, XD; Hu, CX; Zhang, Y; Li, L; Wang, ZG;
Indirizzi:
Third Mil Med Univ, Inst Surg Res, Dept 4, Chongqing 400042, Peoples R China Third Mil Med Univ Chongqing Peoples R China 400042 042, Peoples R China
Titolo Testata:
WOUND REPAIR AND REGENERATION
fascicolo: 3, volume: 9, anno: 2001,
pagine: 205 - 212
SICI:
1067-1927(200105/06)9:3<205:EOCKIP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE; CONTACT INHIBITION; HUMAN FIBROBLASTS; PROLIFERATION; PHASE; OVEREXPRESSION; PROGRESSION; TRANSITION; PROTEIN; ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, ZG Third Mil Med Univ, Inst Surg Res, Dept 4, Chongqing 400042, Peoples R China Third Mil Med Univ Chongqing Peoples R China 400042 les R China
Citazione:
X.D. Zhu et al., "Expression of cyclin-dependent kinase inhibitors, p21(cip1) and p27(kip1),during wound healing in rats", WOUND R REG, 9(3), 2001, pp. 205-212

Abstract

Wound healing is a physiological process in which growth of cells is stringently regulated, Cell growth is controlled by cell cycle-related proteins in which the cyclin kinase inhibitors cause cell cycle arrest and inhibit proliferation, However, little is known about the expression and the role ofcyclin kinase inhibitors during wound healing in vivo, This study was mainly designed to examine the expression of p21(cip1) and p27(kip1) in excisional wounds of full-thickness skin in rats. Concomitant expression of proliferation marker Ki67 was also examined. Proliferation predominantly occurredin the first week after injury, peaking at postwounding day 5. Expression of both p21(cip1) and p27(kip1) at the gene and protein levels did occur during wound healing and showed an inverse gradient to that of Ki67. Constitutive p27(kip1) was expressed throughout wound healing with low levels during the proliferating period of days 3 and 5 and increased levels during post-mitotic and remodeling stages. In contrast, p21(cip1) was expressed transiently with detectable levels only between days 7 and 14 by Western blot analysis. Immunohistochemically, epithelial cells, endothelial cells and fibroblasts all could express both p21(cip1) and p27(kip1). In conclusion, the overall results suggested that p21(cip1) and p27(kip1) may play a key role in supervising the growth resulting from cell proliferation in tissue repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:32:11