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Titolo:
Hyaluronic acid in incision wound fluid: A clinical study with the Cellstick (R) device in children
Autore:
Pajulo, OT; Pulkki, KJ; Lertola, KK; Alanen, MS; Reunanen, MS; Virtanen, RV; Mattila-Vuori, AI; Viljanto, JA;
Indirizzi:
Turku Univ, Cent Hosp, Dept Paediat Surg, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 aediat Surg, FIN-20521 Turku, Finland Turku Univ, Dept Clin Chem, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Clin Chem, Turku, Finland Turku Univ, Dept Stat, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Stat, Turku, Finland Turku Univ, Cent Hosp, Dept Anaesthesiol, Turku, Finland Turku Univ Turku Finland , Cent Hosp, Dept Anaesthesiol, Turku, Finland
Titolo Testata:
WOUND REPAIR AND REGENERATION
fascicolo: 3, volume: 9, anno: 2001,
pagine: 200 - 204
SICI:
1067-1927(200105/06)9:3<200:HAIIWF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY PHASES; LYMPHOCYTES; FIBRONECTIN; PATIENT; SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Pajulo, OT Turku Univ, Cent Hosp, Dept Paediat Surg, POB 52, FIN-20521 Turku, Finland Turku Univ POB 52 Turku Finland FIN-20521 20521 Turku, Finland
Citazione:
O.T. Pajulo et al., "Hyaluronic acid in incision wound fluid: A clinical study with the Cellstick (R) device in children", WOUND R REG, 9(3), 2001, pp. 200-204

Abstract

When inserted into a human incision wound,. the Cellstick(R) device harvests inflammatory cells and collects wound fluid, reflecting time-related changes in cell populations and in wound fluid composition. Hyaluronic acid has been postulated to be an important factor in scar reduction in wound healing and in scarless fetal wound healing. The aim of this work was to determine the concentration and variation of hyaluronic acid and proportions of wound cells in closed surgical wounds in children at two time points. The Cellstick device was inserted subcutaneously into the wound at the end of an elective inguinal hernia operation on 37 healthy boys, and the devices wereremoved 3 +/-1 or 24 +/-3 hours after surgery. Haluronic acid concentration was measured from the wound fluid and a differential count of the wound cells was performed: There was a significant decrease in hyaluronic acid concentration from 3 +/-1 to 24 +/-3 hours after surgery (p<0.001, Kruskal-Wallis anova). The variance of hyaluronic acid concentration in wound fluid differed between the wounds at the two time points (p<0.01, Levene test for homogeneity of variance). A positive correlation between hyaluronic acid concentration and patient age (r=0.91, p<0.05, Spearman) at 3<plus/minus>1 hours post surgery and between HA and wound lymphocytes (r=0.38, p<0.05, Spearman) was also found. We conclude that the hyaluronic acid concentration in wound fluid peaks early in children and decreases significantly by 3 to 24 hours offer surgery, and the concentrations in the wound fluid of healthy boys are more variable 3 hours than at 24 hours after surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:11:12