Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serous tumors of low malignant potential of the ovary-molecular pathology:part 2
Autore:
Hauptmann, S; Dietel, M;
Indirizzi:
Humboldt Univ, Charite Hosp, Inst Pathol, D-10117 Berlin, Germany HumboldtUniv Berlin Germany D-10117 nst Pathol, D-10117 Berlin, Germany
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 6, volume: 438, anno: 2001,
pagine: 539 - 551
SICI:
0945-6317(200106)438:6<539:STOLMP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; MESSENGER-RNA EXPRESSION; COMMON EPITHELIAL TUMORS; P53 PROTEIN EXPRESSION; RAS GENE-MUTATIONS; BORDERLINE TUMORS; PROGNOSTIC-SIGNIFICANCE; E-CADHERIN; IMMUNOHISTOCHEMICAL ANALYSIS; CHROMOSOME-ABERRATIONS;
Keywords:
borderline tumors; tumors of low malignant potential; ovary; serous tumors; genetics; hormone receptors; oncogenes; tumor suppressor genes; inflammation; desmoplasia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Hauptmann, S Humboldt Univ, Charite Hosp, Inst Pathol, Schumannstr 20-21, D-10117 Berlin, Germany Humboldt Univ Schumannstr 20-21 Berlin Germany D-10117 rmany
Citazione:
S. Hauptmann e M. Dietel, "Serous tumors of low malignant potential of the ovary-molecular pathology:part 2", VIRCHOWS AR, 438(6), 2001, pp. 539-551

Abstract

A progressive development from serous tumors of low malignant potential (SLMP) to bluntly invasive serous carcinoma has been suggested in parallel tothe concept of adenoma-carcinoma sequence in colorectal carcinomas. However, recent genetic data enforces a reassessment of the concept that SLMP tumors represent precursor lesions to invasive serous carcinoma. Despite the benign nature of the majority of these tumors, some will behave worse. The identification of those SLMP tumors with an aggressive clinical behavior remains difficult, regardless of a growing body of molecular pathologic investigations. Expression of p53, c-erbB2, as well as the presence of ras mutations are not helpful in this respect. Immunostaining of both MMP-2 and basement membrane components such as collagen type IV, as well as the disintegration of collagen type I at the tumor-host inter-face, may be helpful for the diagnosis of a microinvasive SLMP, but it remains questionable whether this is important for prognosis. The differential diagnosis to frankly invasive carcinoma depends on the detection of destructive stromal invasion. In questionable cases, the loss of N-cadherin would argue for the presence of acarcinoma whereas the coexpression of p21 and MDM2 is rather characteristic for SLMP tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:14:44