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Titolo:
Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients
Autore:
Kasajima, H; Yamagishi, SI; Sugai, S; Yagihashi, N; Yagihashi, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Pathol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 439, anno: 2001,
pagine: 46 - 54
SICI:
0945-6317(200107)439:1<46:EISEOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SORBITOL DEHYDROGENASE; GENE-EXPRESSION; ACE-INHIBITION; MESSENGER-RNA; NEPHROPATHY; RATS; POLYMORPHISM; COMPLICATIONS; ACCUMULATION; MELLITUS;
Keywords:
aldose reductase; sorbitol dehydrogenase; diabetes; nephropathy; neuropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Yagihashi, N Hirosaki Univ, Sch Med, Dept Pathol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 Japan
Citazione:
H. Kasajima et al., "Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients", VIRCHOWS AR, 439(1), 2001, pp. 46-54

Abstract

To explore the relationships between polyol pathway-related enzymes and pathologic features, we examined the immunohistochemical expression of aldosereductase (AR) and sorbitol dehydrogenase (SDH) in the peripheral nerve and kidney tissues collected postmortem from diabetic patients and compared it with those from non-diabetic patients. Tissue AR protein concentrations were also quantified. In non-diabetic patients, AR distributed in pericytes,smooth muscle cells of endo-and epi-neurial microvessels. Schwann cells inthe sciatic nerve, and tubular cells of the renal medulla. By contrast, positive SDH reactions were observed in tubular cells of the renal cortex butwere faint in the sciatic nerve. Diabetic patients frequently showed denseAR expressions in the sciatic nerve. In nephropathic diabetic patients, the glomerular mesangial area showed diffuse positive reactions for AR. The severity of structural changes in glomeruli correlated with the intensity ofimmunoreactive AR (r(2)=0.626. P <0.01). AR contents in the renal cortex and sciatic nerve from diabetic patients were 1.5- and 1.8-fold greater thanthose from non-diabetic patients, respectively (P <0.05 for both). These findings are the first to demonstrate enhanced AR expressions in peripheral nerve and renal glomeruli in diabetic patients and its relevance to the characteristic pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:40:47