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Titolo:
Associations of lead exposure and dose measures with erythrocyte protein kinase C activity in 212 current Korean lead workers
Autore:
Hwang, KY; Schwartz, BS; Lee, BK; Strickland, PT; Todd, AC; Bressler, JP;
Indirizzi:
Johns Hopkins Univ, Dept Environm Hlth Sci, Div Toxicol Sci, Sch Hyg & Publ Hlth, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 l Hlth, Baltimore, MD 21205 USA Soonchunhyang Univ, Sch Med, Dept Prevent Med, Chunan, South Korea Soonchunhyang Univ Chunan South Korea Prevent Med, Chunan, South Korea Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA h, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA Mt Sinai Med Ctr, Dept Community Med & Prevent Med, New York, NY 10029 USAMt Sinai Med Ctr New York NY USA 10029 revent Med, New York, NY 10029 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Kennedy Krieger Inst, Dept Neurotoxicol, Baltimore, MD21205 USA Johns Hopkins Univ Baltimore MD USA 21205 toxicol, Baltimore, MD21205 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 62, anno: 2001,
pagine: 280 - 288
SICI:
1096-6080(200108)62:2<280:AOLEAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANOLEAD MANUFACTURING WORKERS; MEMBRANE SKELETAL PROTEINS; RAT-BRAIN; PLASMA-MEMBRANE; CHELATABLE LEAD; INORGANIC LEAD; TIBIAL LEAD; BLOOD LEAD; PHOSPHORYLATION; CALCIUM;
Keywords:
blood lead; tibia lead; protein kinase C; back-phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bressler, JP Johns Hopkins Univ, Dept Environm Hlth Sci, Div Toxicol Sci, Sch Hyg & Publ Hlth, Room 7032,615 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ Room 7032,615 N Wolfe St Baltimore MD USA 21205
Citazione:
K.Y. Hwang et al., "Associations of lead exposure and dose measures with erythrocyte protein kinase C activity in 212 current Korean lead workers", TOXICOL SCI, 62(2), 2001, pp. 280-288

Abstract

Lead can replace calcium in enzyme assays that measure protein kinase C activity and lead activates protein kinase C in human erythrocytes after exposure to lead in vitro. To examine the relevance of these observations to lead exposure in humans, we studied the associations of lead found in blood or tibia with activation of protein kinase C in erythrocytes isolated from workers in the lead industry. We examined erythrocytes among 212 lead workers, with a mean (+/- SD) age of 39.1 (10.0) years and exposure duration of 8.1 (6.5) years and measured protein kinase C activation by an in vitro back-phosphorylation assay. After adjustment for potential confounding factors (age and sex), tibia lead and exposure duration were significantly associated with erythrocyte protein kinase C activation (both p values < 0.05). No associations were observed between protein kinase C activation and blood-lead or zinc-protoporphyrin levels. These findings suggest that human exposure to lead results in activation of erythrocyte protein kinase C, which may be directly relevant to the neurotoxicity of lead.

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Documento generato il 02/04/20 alle ore 17:56:54