Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy
Autore:
Moretto, A; Gardiman, G; Panfilo, S; Colle, MA; Lock, EA; Lotti, M;
Indirizzi:
Univ Padua, Dipartimento Med Ambientale & Sanita Pubbl, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 tale & Sanita Pubbl, I-35128 Padua, Italy Zeneca Cent Toxicol Lab, Alderley Pk, Cheshire, England Zeneca Cent Toxicol Lab Alderley Pk Cheshire England , Cheshire, England INSERM U306, Lab Neuropathol R Escourolle, Paris, France INSERM U306 Paris France 6, Lab Neuropathol R Escourolle, Paris, France
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 62, anno: 2001,
pagine: 274 - 279
SICI:
1096-6080(200108)62:2<274:EOSH(O>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED NEUROTOXICITY; ORTHO-CRESYL PHOSPHATE; TARGET ESTERASE; PHENYLMETHANESULFONYL FLUORIDE; PHENYLMETHYLSULFONYL FLUORIDE; REPRODUCTIVE TOXICITY; TESTICULAR TOXICITY; CLINICAL EXPRESSION; SCIATIC-NERVE; SPINAL-CORD;
Keywords:
OP neuropathy; protection; promotion; molinate; organophosphate; esterase; pathology; inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Lotti, M Univ Padua, Dipartimento Med Ambientale & Sanita Pubbl, Via Giustiniani 2,I-35128 Padua, Italy Univ Padua Via Giustiniani 2 Padua Italy I-35128 28 Padua, Italy
Citazione:
A. Moretto et al., "Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy", TOXICOL SCI, 62(2), 2001, pp. 274-279

Abstract

Certain esterase inhibitors protect from organophosphate-induced delayed polyneuropathy (OPIDP) when given before a neuropathic organophosphate by inhibiting neuropathy target esterase (NTE). In contrast, they can exaggerateOPIDP when given afterwards and this effect (promotion) is associated withinhibition of another esterase (M200). In vitro sensitivities of hen, rat,and human NTE and M200 to the active metabolites of molinate, sulfone, andsulfoxide, were similar. NTE and M200 were irreversibly inhibited (> 78%) in brain and peripheral nerve of hens and rats given molinate (100-180 mg/kg, sc). No clinical or morphological signs of neuropathy developed in theseanimals. Hens and rats were protected from di-n-butyl dichlorovinyl phosphate neuropathy (DBDCVP, 1 and 5 mg/kg, se, respectively) by molinate (180 or 100 mg/kg, sc, 24 h earlier, respectively) whereas 45 mg/kg, sc molinate causing about 34% NTE inhibition offered partial protection to hens. Hens treated with DBDCVP (0.4 mg/kg, sc) developed a mild OPIDP; molinate (180 mg/kg, 24 h later) increased the severity of clinical effects and of histopathology in spinal cord and in peripheral nerves. Lower doses of molinate (45mg/kg, sc), causing about 47% M200 inhibition, did not promote OPIDP whereas the effect of 90 mg/kg, sc (corresponding to about 50-60% inhibition) was mild and not statistically significant. OPIDP induced by DBDCVP (5 mg/kg,sc) in rats was promoted by molinate (100 mg/kg, sc). In conclusion, protection from DBDCVP neuropathy by molinate is correlated with inhibition of NTE whereas promotion of DBDCVP neuropathy is associated with > 50% M200 inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 22:23:25