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Titolo:
Nelfinavir plasma levels under twice-daily and three-times-daily regimens:High interpatient and low intrapatient variability
Autore:
Marzolini, C; Buclin, T; Decosterd, LA; Biollaz, J; Telenti, A;
Indirizzi:
Univ Lausanne Hosp, CHU Vaudois, Dept Med, Div Clin Pharmacol, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHU Vaudois, Dept Med, Div Infect Dis, Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland fect Dis, Lausanne, Switzerland
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 4, volume: 23, anno: 2001,
pagine: 394 - 398
SICI:
0163-4356(200108)23:4<394:NPLUTA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-PROTEASE INHIBITORS; INFECTED PATIENTS; THERAPY; PHARMACOKINETICS; INDINAVIR; EFAVIRENZ;
Keywords:
dosing regimen; drug monitoring; interpatient and intrapatient variability; nelfinavir; plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Buclin, T Univ Lausanne Hosp, CHU Vaudois, Dept Med, Div Clin Pharmacol, Beaumont 06-633, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Beaumont 06-633 Lausanne Switzerland CH-1011
Citazione:
C. Marzolini et al., "Nelfinavir plasma levels under twice-daily and three-times-daily regimens:High interpatient and low intrapatient variability", THER DRUG M, 23(4), 2001, pp. 394-398

Abstract

Nelfinavir has been recently approved as a twice-daily (BID) dose regimen,but no evaluation of the influence of this regimen change on patients' protease inhibitor exposure has been published. The aim of this study was to compare trough plasma concentrations of nelfinavir obtained under the 1250-mg b.i.d regimen with the levels achieved with the original 750-mg three-times-daily (TID) regimen in 56 HIV-infected patients. Blood samples were obtained at steady state before the morning dose of nelfinavir. Plasma levels were measured by high-performance liquid chromatography. Eleven and 45 patients were following TID and BID regimens, respectively. Trough concentrations ranged from 0.14 to 11.74 mg/L and from 0.36 to 10.57 mg/L under TID and BED regimens, respectively. Large interpatient (coefficient of variation: 153%) and modest intrapatient (45%) variabilities of nelfinavir levels were observed. Twenty-one patients (38%) and six patients (11%) had levels aboveand below, respectively, the trough nelfinavir range (1.0-3.0 mg/L) recommended by the manufacturer. Trough levels are not affected by the dosing regimen; they mainly reflect the important interindividual variability, while remaining fairly stable over time. Many subjects had plasma levels repeatedly outside the assumed therapeutic range. Dose adjustment based on therapeutic drug monitoring may contribute to optimizing antiretroviral therapy.

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Documento generato il 04/04/20 alle ore 03:01:51