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Titolo:
A convenient and high yield method to prepare 4-hydroxypyroglutamic acids
Autore:
Zhang, XJ; Schmitt, AC; Jiang, W;
Indirizzi:
Dupont Merck Pharmaceut Co, Expt Stn, Chem & Phys Sci, Wilmington, DE 19880 USA Dupont Merck Pharmaceut Co Wilmington DE USA 19880 lmington, DE 19880 USA
Titolo Testata:
TETRAHEDRON LETTERS
fascicolo: 32, volume: 42, anno: 2001,
pagine: 5335 - 5338
SICI:
0040-4039(20010806)42:32<5335:ACAHYM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOSPECIFIC SYNTHESIS; ASYMMETRIC-SYNTHESIS; AMINO-ACIDS; PYROGLUTAMATE; EFFICIENT;
Keywords:
4-hydroxyl pyroglutamic acid; ruthenium dioxide; oxidation; Mitsunobu reaction; N-acyliminium ion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, XJ Dupont Merck Pharmaceut Co, Expt Stn, Chem & Phys Sci, POB 80500, Wilmington, DE 19880 USA Dupont Merck Pharmaceut Co POB 80500 Wilmington DE USA 19880 USA
Citazione:
X.J. Zhang et al., "A convenient and high yield method to prepare 4-hydroxypyroglutamic acids", TETRAHEDR L, 42(32), 2001, pp. 5335-5338

Abstract

RuO2/NaIO4 oxidation of N-Boc-4-silyloxy and 4-acetoxy proline methyl esters under ethyl acetate/water biphase condition gave N-Boc-4-silyloxy and 4-acetoxy pyroglutamic acid derivates in high yields. Desilylation with TBAF afforded both cis- and trans-N-Boc-methyl-4-hydroxy pyroglutamates. (C) 2001 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:13:53