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Titolo:
Age differences in muscarinic cholinergic receptors assayed with (+)N-[C-11]methy-3-piperidyl benzilate in the brains of conscious monkeys
Autore:
Tsukada, H; Kakiuchi, T; Nishiyama, S; Ohba, H; Sato, K; Harada, N; Takahashi, K;
Indirizzi:
Hamamatsu Photon KK, Cent Res Lab, Shizuoka 4348601, Japan Hamamatsu Photon KK Shizuoka Japan 4348601 Lab, Shizuoka 4348601, Japan Res Inst Brain & Blood Vessels, Dept Radiol & Nucl Med, Akita 0100874, Japan Res Inst Brain & Blood Vessels Akita Japan 0100874 Akita 0100874, Japan
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 41, anno: 2001,
pagine: 248 - 257
SICI:
0887-4476(200109)41:3<248:ADIMCR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; C-11 RACLOPRIDE BINDING; IN-VIVO; ALZHEIMERS-DISEASE; RHESUS-MONKEY; RAT-BRAIN; PET; MICRODIALYSIS; QUANTIFICATION; EQUILIBRIUM;
Keywords:
aging; muscarinic. receptor; N-[C-11]methyl-3-piperidyl benzilate; cortisol; monkey brain; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, H Hamamatsu Photon KK, Cent Res Lab, 5000 Hirakuchi, Shizuoka 4348601, Japan Hamamatsu Photon KK 5000 Hirakuchi Shizuoka Japan 4348601 apan
Citazione:
H. Tsukada et al., "Age differences in muscarinic cholinergic receptors assayed with (+)N-[C-11]methy-3-piperidyl benzilate in the brains of conscious monkeys", SYNAPSE, 41(3), 2001, pp. 248-257

Abstract

Age-related changes in muscarinic cholinergic receptors were evaluated with the novel ligand (+)N-[C-11]methyl-3-piperidyl benzilate ((+)3-MPB) in the living brains of young. (5.9 +/- 1.8 years old) and aged (19.0 +/- 3.3 years old) monkeys (Macaca mulatta) in the conscious state using high-resolution positron emission tomography (PET). For quantitative analysis of receptor binding in vivo, metabolite-corrected arterial plasma radioactivity curves were obtained as an input function into the brain, and kinetic analyses using the three-compartment model and graphical Logan plot analysis were applied. Kinetic analyses of [C-11](+)3-MPB indicated a regionally specific decrease in the receptor binding in vivo determined as binding potential (BP) = k(3)/k(4) in aged animals compared with young animals. Thus, the frontal and temporal cortices as well as the striatum showed age-related reduction of muscarinic cholinergic receptors in vivo, reflecting the reduced receptor density (B-max) determined by Scatchard plot analysis in vivo, In the hippocampus, although BP of [C-11](+)3-MPB indicated no significant age-related changes, it showed an inverse correlation with individual cortisol levels in plasma. When the graphical Logan plot analysis was applied, all regions assayed showed significant age-related decrease of [C-11](+)3-MPB binding. These results demonstrate the usefulness of kinetic three-compartment model analysis of [C-11](+)3-MPB with metabolite-corrected arterial plasma input as an indicator for the aging process of the cortical muscarinic cholinergic receptors in vivo as measured by PET. Synapse 41: 248-257,2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:14:09