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Titolo:
Loss of metabolites from monkey striatum during PET with FDOPA
Autore:
Cumming, P; Munk, OL; Doudet, D;
Indirizzi:
Arhus Kommunehosp, PET Ctr, Aarhus, Denmark Arhus Kommunehosp Aarhus Denmark Kommunehosp, PET Ctr, Aarhus, Denmark Univ British Columbia, PET Ctr, Vancouver, BC V5Z 1M9, Canada Univ BritishColumbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 41, anno: 2001,
pagine: 212 - 218
SICI:
0887-4476(200109)41:3<212:LOMFMS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MPTP-INDUCED PARKINSONISM; LIVING HUMAN BRAIN; 6-FLUORO-L-DOPA METABOLISM; DOPA; TURNOVER; KINETICS; DISEASE; VOLUME; RAT;
Keywords:
[F-18]fluorodopa; DOPA decarboxylase; striatum; MPTP; kinetics; irreversibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cumming, P Arhus Kommunehosp, PET Ctr, Aarhus, Denmark Arhus Kommunehosp Aarhus Denmark p, PET Ctr, Aarhus, Denmark
Citazione:
P. Cumming et al., "Loss of metabolites from monkey striatum during PET with FDOPA", SYNAPSE, 41(3), 2001, pp. 212-218

Abstract

The decarboxylation of 6-[F-18]fluorodopa (FDOPA) and retention of the product [F-18]fluorodopamine within vesicles of catecholamine fibers results in the labeling of dopamine-rich brain regions during FDOPA/PET studies. However, this metabolic trapping is not irreversible due to the eventual diffusion of [F-18]fluorodopamine metabolites from brain. Consequently, time-radioactivity recordings of striatum are progressively influenced by metabolite loss. In linear analyses, the net blood-brain clearance of FDOPA (K-i(D),ml g(-1) min(-1)) can be corrected for this loss by the elimination rate constant k(cl)(Lin) (min(-1)). Similarly,. the DOPA decarboxylation rate constant (k(3)(D), min(-1)) calculated by compartmental analysis can also be corrected for metabolite loss by the elimination rate constant k(9)(DA) (min(-1)). To compare the two methods, we calculated the two elimination rate, constants using data recorded during 240 min of FDOPA circulation in normalmonkeys and in monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesions. Use of the extended models increased the magnitudes of K-i(D) and k(3)(D) in striatum; in the case of k(3)(D), variance of the estimate was substantially improved upon correction for metabolite loss. The rate constants for metabolite loss were higher in MPTP-lesioned monkeystriatum than in normal striatum. The high correlation between individual estimates of k(cl)(Lin) and k(9)(DA) suggests that both rate constants reveal loss of decarboxylated metabolites from brain. Synapse 41:212-218, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:22:17