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Titolo:
Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats
Autore:
Haile, CN; Hiroi, N; Nestler, EJ; Kosten, TA;
Indirizzi:
Yale Univ, Sch Med, Div Subst Abuse, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 Div Subst Abuse, New Haven, CT 06508 USA Yale Univ, Sch Med, Div Mol Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 iv Mol Psychiat, New Haven, CT 06508 USA Connecticut Mental Hlth Ctr, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Hlth Ctr, New Haven, CT USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 41, anno: 2001,
pagine: 179 - 190
SICI:
0887-4476(200109)41:3<179:DBRTCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; CONDITIONED PLACE PREFERENCE; FIBRILLARY ACIDIC PROTEIN; CHRONIC MORPHINE; NUCLEUS-ACCUMBENS; LOCOMOTOR-ACTIVITY; NEUROFILAMENT PROTEINS; TYROSINE-HYDROXYLASE; SPRAGUE-DAWLEY; C57BL/6J MICE;
Keywords:
inbred rat strains; psychostimulants; dopamine; stereotypy; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Kosten, TA Yale Univ, Sch Med, Div Subst Abuse, Room S-305 CMHC,34 Pk St, New Haven, CT 06508 USA Yale Univ Room S-305 CMHC,34 Pk St New Haven CT USA06508 8 USA
Citazione:
C.N. Haile et al., "Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats", SYNAPSE, 41(3), 2001, pp. 179-190

Abstract

Differential behavioral and biochemical responses to drugs of abuse may reflect genetic makeup as suggested by studies of inbred Lewis (LEW) and Fischer 344 (F344) rats. We investigated locomotor activity, stereotypy signs, and levels of specific proteins in the nucleus accumbens (NAc) and ventral tegmental area (VTA) in these strains at baseline and following chronic administration of cocaine (30 mg/kg/day for 14 days). Using Western blot analysis, we replicated our previous findings of baseline strain differences andfound lower levels of Delta FosB immunoreactivity in NAc of F344 vs. LEW rats. F344 rats showed greater baseline locomotor activity, sniffing, and grooming compared to LEW rats. Chronic cocaine increased Delta FosB levels inNAc in both strains, whereas adaptations in other proteins were induced inF344 rats only. These included reduced levels of tyrosine hydroxylase (TH)in NAc and increased TH and glial fibrillary acidic protein (GFAP) immunoreactivity in VTA. Chronic cocaine led to greater increases in overall stereotypy in F344 vs. LEW rats and decreased exploratory behaviors in LEW rats. Opposing effects by strain were seen in locomotor activity. Whereas F344 rats showed higher initial activity levels that decreased with cocaine exposure (tolerance), LEW rats showed increased activity over days (sensitization) with no strain differences seen at 14 days. Further, conditioned locomotor activation to vehicle injections was greater in F344 vs. LEW rats. Theseresults suggest that behavioral responsiveness to chronic cocaine exposuremay reflect dynamics of mesolimbic dopamine protein levels and demonstratethe role of genetic background in responsiveness to cocaine. Synapse 41:179-190, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 27/01/20 alle ore 08:09:31