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Titolo:
Prenatal exposure to cocaine reduces the number and enhances reactivity ofA10 dopaminergic neurons to environmental stress
Autore:
Morrow, BA; Elsworth, JD; Roth, RH;
Indirizzi:
Yale Univ, Sch Med, Dept Pharmacol, Neuropharmacol Lab, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ropharmacol Lab, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Psychiat, Neuropharmacol Lab, New Haven, CT 06520USA Yale Univ New Haven CT USA 06520 uropharmacol Lab, New Haven, CT 06520USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 41, anno: 2001,
pagine: 337 - 344
SICI:
0887-4476(20010915)41:4<337:PETCRT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; SUBSTANTIA-NIGRA; WORKING-MEMORY; TARGETED DISRUPTION; RAT; REVERSAL; CATECHOLAMINES; PEROXIDASE; EXPRESSION; VOLUME;
Keywords:
tyrosine hydroxylase; fos; c-fos; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Morrow, BA Yale Univ, Sch Med, Dept Pharmacol, Neuropharmacol Lab, 333 Cedar St, New Haven, CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
B.A. Morrow et al., "Prenatal exposure to cocaine reduces the number and enhances reactivity ofA10 dopaminergic neurons to environmental stress", SYNAPSE, 41(4), 2001, pp. 337-344

Abstract

Prenatal exposure to cocaine has been shown to result in poor cognitive performance in the resulting offspring in humans and laboratory animals. The underlying biochemical changes that contribute to these behavioral effects are not known but have been proposed to involve changes in dopaminergic function. In these studies, we exposed rats to cocaine in utero using the clinically relevant intravenous model and report a mean loss of 24.8% of the tyrosine hydroxylase immunoreactive, presumed dopaminergic, neurons in the A10, but not A9 and A8, cell groups of the young adult offspring. Additionally, in prenatal cocaine-exposed rats dopaminergic neurons in the ventral, midline A10, and lateral A9 regions demonstrated a hyperreactivity to environmental stress, as measured by activation of the immediate-early gene, Fos. Mild, intermittent footshock did not further increase the number of dopamine neurons expressing Fos in prenatal cocaine-exposed rats, as it did in theprenatal saline controls. Because the exposure to cocaine took place during development, other potential changes in dopaminergic and nondopaminergic neuronal systems could result from the cocaine-induced reduction in numbersof A10 dopamine neurons. We hypothesize that a perinatal loss of A10 dopamine neurons, and subsequent developmental changes, contributes to a dysregulation of the adult mesoprefrontal system, resulting in the reported cognitive deficits. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:42:17