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Titolo:
Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers
Autore:
Suzuki, M; Desmond, TJ; Albin, RL; Frey, KA;
Indirizzi:
Jikei Univ, Sch Med, Dept Neurol, Tokyo, Japan Jikei Univ Tokyo JapanJikei Univ, Sch Med, Dept Neurol, Tokyo, Japan Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI 48105 USA Vet Adm Med Ctr Ann Arbor MI USA 48105 uc & Clin, Ann Arbor, MI 48105 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA , Mental Hlth Res Inst, Ann Arbor, MI USA Univ Michigan, Dept Neurol, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA Michigan, Dept Neurol, Ann Arbor, MI USA Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 41, anno: 2001,
pagine: 329 - 336
SICI:
0887-4476(20010915)41:4<329:VNTIHD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; H-3 VESAMICOL BINDING; CHOLINE-ACETYLTRANSFERASE; SUBSTANTIA-NIGRA; MONOAMINE TRANSPORTER; PARKINSONS-DISEASE; STRIATAL NEURONS; RECEPTOR-BINDING; MONKEY BRAIN; DOPAMINE;
Keywords:
VAChT; VMAT2; choline acetyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Frey, KA Univ Michigan Hosp, B1G 412-0028 AGH,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan Hosp B1G 412-0028 AGH,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
M. Suzuki et al., "Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers", SYNAPSE, 41(4), 2001, pp. 329-336

Abstract

Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by effects of compensatory regulation and atrophy. Studies of the vesicular monoamine transporter type-2 (V-VMAT2) and of the vesicular acetylcholine transporter (VAChT) in experimental animals indicate that they are robust markers of presynaptic integrity and are not subject to regulation. We measured dopamine and acetylcholine vesicular transporters to characterize the selectivity of degeneration in HD striatum. Brains were obtained at autopsy from four HD patients and five controls. Autoradiography was used to quantify radioligand binding to VMAT2, VAChT, the dopamine plasmalemmal transporter (DAT), benzodiazepine (BZ) binding sites, and D2-type dopamine receptors. The activity of choline acetyltransferase (ChAT) was determined as an additional marker of cholinergic neurons. Autoradiograms were analyzed by video-assisted densitometry and assessment of atrophy was made from regional structural areas in the coronal projection. Striatal VMAT2, DAT, and VAChT concentrations were unchanged or increased, while D2 and BZ binding and ChAT activity were decreased in HD. After atrophy correction, all striatal binding sites were decreased. However,the decrease in ChAT activity was 3-fold greater than that of VAChT binding. In addition to degeneration of striatal projection neurons, there are losses of extrinsic nigrostriatal projections and of striatal cholinergic interneurons in HD on the basis of vesicular transporter measures. There is also markedly reduced expression of ChAT by surviving cholinergic striatal interneurons. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 06:12:03