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Titolo:
Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors
Autore:
Lee, TH; Balu, R; Davidson, C; Ellinwood, EH;
Indirizzi:
Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ed Ctr, Dept Psychiat, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Pharmacol, Durham, NC 27710 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 41, anno: 2001,
pagine: 301 - 310
SICI:
0887-4476(20010915)41:4<301:DTPODR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAST CYCLIC VOLTAMMETRY; TRANSPORTER KNOCKOUT MICE; RAT-BRAIN SLICES; NUCLEUS-ACCUMBENS; COCAINE; STRIATUM; NOMIFENSINE; EFFLUX; RECEPTOR; BINDING;
Keywords:
voltammetry; accumbens slice; cocaine; WIN 35428; nomifensine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, TH Duke Univ, Med Ctr, Dept Psychiat, Box 3870, Durham, NC 27710 USA Duke Univ Box 3870 Durham NC USA 27710 3870, Durham, NC 27710 USA
Citazione:
T.H. Lee et al., "Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors", SYNAPSE, 41(4), 2001, pp. 301-310

Abstract

Using real-time voltammetry, we compared the effects of cocaine (1.0, 3.0,or 10 muM), WIN 35428 (0.1, 0.5, or 2.0 muM), and nomifensine (0.2, 1.0, or 5.0 muM) on electrically evoked dopamine release and uptake in the rat accumbens slice. The time course for onset and offset of the drug effects were determined by perfusing single drug concentration for 30 min, followed bya 60-min washout. Cocaine elicited a rapid, concentration-independent increase in dopamine release and a more gradual, concentration-dependent inhibition of uptake. During washout, uptake inhibition rapidly abated to near baseline values. During the same period, the potentiation of dopamine releaseexhibited a slower offset for all concentrations and, for 10 muM cocaine, was even greater than that observed during drug perfusion ("rebound" increase). The release rebound was not observed during continuous 90-min perfusion, verifying that cocaine washout per se was a sufficient condition. Selective D-1 or D-2 antagonists (0.5 muM SCH 39166 or 2 muM sulpiride, respectively) were without effect on cocaine-induced release alterations. WIN 35428 and nomifensine induced similar changes in dopamine kinetics during perfusion. However, in contrast to cocaine, no consistent release rebound was observed during their washout, For 2 muM WIN 38425, washout and continuous perfusion groups exhibited similar changes in dopamine release and uptake. The time-course mismatch between uptake inhibition and DA release potentiation as well as release rebound during washout suggests that altered dopamine release might play a role in behavioral effects of cocaine. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 17:06:35