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Titolo:
Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug
Autore:
Jardemark, KE; Ai, JL; Ninan, I; Wang, RY;
Indirizzi:
SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Sci, Stony Brook, NY 11794 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 41, anno: 2001,
pagine: 294 - 300
SICI:
0887-4476(20010915)41:4<294:BMONRI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; INVERSE AGONIST ACTIVITY; VOLTAGE-CLAMP ANALYSIS; 5-HT2A RECEPTOR ANTAGONIST; NEURONS IN-VITRO; 5-HYDROXYTRYPTAMINE(2A) RECEPTOR; BASOLATERAL AMYGDALA; FRONTAL-CORTEX; CLOZAPINE; SCHIZOPHRENIA;
Keywords:
antipsychotic drugs; Y-931; NMDA; AMPA; PCP; medial prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Jardemark, KE SUNY Stony Brook, Dept Psychiat & Behav Sci, Putman Hall,South Campus, Stony Brook, NY 11794 USA SUNY Stony Brook Putman Hall,South Campus Stony Brook NY USA 11794
Citazione:
K.E. Jardemark et al., "Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug", SYNAPSE, 41(4), 2001, pp. 294-300

Abstract

Similar to the effects produced by the atypical antipsychotic drugs (APDs)clozapine and olanzapine, Y-931 {8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno [2,3-b] [1,5]benzodiazepine maleate, a purported atypical APD} effectively facilitated N-methyl-D-aspartate (NMDA)-induced, but not (+/-)-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-evoked, responses in pyramidal cells of the rat medial prefrontal cortex (mPFC). Similar to olanzapine and clozapine, the concentration-response curve of Y-931 in these experiments was biphasic. At present, the mechanisms behind the biphasic modulatory actions of Y-931 and olanzapine on NMDA-induced currents in the mPFC are not clear. In addition to augmenting NMDA responses, Y-931 prevented the phencyclidine (PCP)-induced block of the NMDA responses andincreased the amplitudes and durations of excitatory postsynaptic currents(EPSCs) evoked by electrical stimulation of the forceps minor. Overall, our findings suggest that APDs, particularly the atypical ones, share a common property in that they facilitate NMDA receptor-mediated transmission in the mPFC and perhaps other functionally related limbic structures as well, which could be the cellular basis for their ability to alleviate some schizophrenic negative symptoms and cognitive dysfunctions. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 03/04/20 alle ore 20:33:34