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Titolo:
Sex differences in [I-123]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
Autore:
Staley, JK; Krishnan-Sarin, S; Zoghbi, S; Tamagnan, G; Fujita, M; Seibyl, JP; Maciejewski, PK; OMalley, S; Innis, RB;
Indirizzi:
Yale Univ, Dept Psychiat, Sch Med, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 t Psychiat, Sch Med, W Haven, CT 06516 USA Yale Univ, Dept Pharmacol, Sch Med, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Pharmacol, Sch Med, W Haven, CT 06516 USA VA Connecticut Healthcare Syst, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 41, anno: 2001,
pagine: 275 - 284
SICI:
0887-4476(20010915)41:4<275:SDI[SM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; FAGERSTROM TOLERANCE QUESTIONNAIRE; EMISSION COMPUTED-TOMOGRAPHY; BRAIN MONOAMINE-OXIDASE; H-3 PAROXETINE BINDING; SERT MESSENGER-RNA; RAT-BRAIN; UPTAKE SITES; MAJOR DEPRESSION; REGIONAL DISTRIBUTION;
Keywords:
nicotine; male; female; brain; reuptake; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Staley, JK Yale Univ, Dept Psychiat, Sch Med, 950 Campbell Ave, W Haven, CT 06516 USA Yale Univ 950 Campbell Ave W Haven CT USA 06516 n, CT 06516 USA
Citazione:
J.K. Staley et al., "Sex differences in [I-123]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers", SYNAPSE, 41(4), 2001, pp. 275-284

Abstract

Nicotine and other constituents of tobacco smoke elevate dopamine (DA) andserotonin (5-HT) levels in brain and may cause homeostatic adaptations in DA and 5-HT transporters. Since sex steroids alter DA and 5-HT transporter expression, the effects of smoking on DA and 5-HT transporter availability may differ between sexes. In the present study, DA and 5-HT transporter availabilities were quantitated using single photon emission computed tomography (SPECT) imaging approximately 22 h after bolus administration of [I-123]beta -CIT, an analog of cocaine which labels DA and 5-HT transporters. Forty-two subjects including 21 pairs of age-, race-, and gender-matched healthy smokers and nonsmokers (12 female and 9 male pairs) were imaged. Regionaluptake was assessed by the outcome measures, V-3", which is the ratio of specific (i.e., ROI-cerebellar activity) to nondisplaceable (cerebellar) activity, and V-3, the ratio of specific to free plasma parent. Overall, striatal and diencephalic [I-123] beta -CIT uptake was not altered by smoking, whereas brainstem [I-123] beta -CIT uptake was modestly higher (10%) in smokers vs. nonsmokers. When subgrouped by sex, regardless of smoking status, [I-123] beta -CIT uptake was higher in the striatum (10%), diencephalon (15%), and brainstem (15%) in females vs. males. The sex*smoking interaction was not significant in the striatum, diencephalon, or brainstem, despite the observation of 20% higher brainstem [I-123] beta -CIT uptake in male smokers vs. nonsmokers and less than a 5% difference between female smokers and nonsmokers. The results demonstrate higher DA and 5-HT transporter availability in females vs. males and no overall effect of smoking with the exception of a modest elevation in brainstem 5-HT transporters in male smokers. Although these findings are preliminary and need validation with a more selective 5-HT transporter radiotracer, the results suggest that brainstem 5-HT transporters may be regulated by smoking in a sex-specific manner. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:32:03