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Titolo:
Sympathetic stimulation using the cold pressor test increases coronary collateral flow
Autore:
de Marchi, SF; Schwerzmann, M; Billinger, M; Windecker, S; Meier, B; Seiler, C;
Indirizzi:
Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 Bern, CH-3010 Bern, Switzerland
Titolo Testata:
SWISS MEDICAL WEEKLY
fascicolo: 23-24, volume: 131, anno: 2001,
pagine: 351 - 356
SICI:
1424-7860(20010616)131:23-24<351:SSUTCP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENERGIC RECEPTORS; HUMAN MUSCLE NERVES; ENDOTHELIAL DYSFUNCTION; GENERAL CHARACTERISTICS; ISCHEMIA;
Keywords:
coronary collateral circulation; ischaemic preconditioning; walking through angina; sympathetic nervous system; cold pressor test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Seiler, C Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, Freiburgstr, CH-3010 Bern, Switzerland Univ Hosp Bern Freiburgstr Bern Switzerland CH-3010 Switzerland
Citazione:
S.F. de Marchi et al., "Sympathetic stimulation using the cold pressor test increases coronary collateral flow", SWISS MED W, 131(23-24), 2001, pp. 351-356

Abstract

Background: Little is known about the vasomotor function of human coronarycollateral vessels. The purpose of this study was to examine collateral flow under a strong sympathetic stimulus (cold pressor test, CPT). Methods: In 30 patients (62 +/- 12 years) with coronary artery disease, two subsequent coronary artery occlusions were performed with random CPT during one of them. Two minutes before and during the 1 minute-occlusion, the patient's hand was immerged in ice water. For the calculation of a perfusionpressure-independent collateral flow index (CFI), the aortic (P-ao), the central venous (CVP) and the coronary wedge pressure (P-occl) were measured:CFI = (P-occl- CvP) / (P-ao - CVP). Results: CPT lead to an increase in P-ao from 98 +/- 14 to 105 +/- 15 mm Hg (p = 0.002). Without and with CPT, CFI increased during occlusion from 14% +/- 10% to 16% +/- 10% (p = 0.03) and from 17% +/- 9% to 19% +/- 9% (p = 0.006), respectively, relative to normal flow. During CPT, CFI was significantly higher at the beginning as well as at the end of the occlusion compared to identical instants without CPT. CFI at the end of the control occlusion did not differ significantly from the CFI at the beginning of occlusion with CPT. Conclusions: During balloon occlusion, collateral flow increased due to collateral recruitment independent of external sympathetic stimulation. Sympathetic stimulation using CPT additionally augmented collateral flow. The collateral-flow-increasing effect of CPT is comparable to the recruitment effect of the occlusion itself. This may reflect a coronary collateral vasodilation mediated by the sympathetic nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 20:47:50