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Titolo:
Determination of acid dissociation constants of neamine by potentiometric and electrospray mass spectral techniques
Autore:
Sutrisno; Baran, Y; Lawrance, GA; von Nagy-Felsobuki, EI;
Indirizzi:
Univ Newcastle, Sch Biol & Chem Sci, Callaghan, NSW 2308, Australia Univ Newcastle Callaghan NSW Australia 2308 allaghan, NSW 2308, Australia Univ Karaelmas, Dept Chem, TR-67100 Zonguldak, Turkey Univ Karaelmas Zonguldak Turkey TR-67100 hem, TR-67100 Zonguldak, Turkey
Titolo Testata:
STRUCTURAL CHEMISTRY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 189 - 195
SICI:
1040-0400(200104)12:2<189:DOADCO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
3'-PHOSPHOTRANSFERASE TYPE IIA; TYROSINE-HYDROXYLASE; MOLECULAR TEMPLATE; SPECTROMETRY; IONIZATION; PHOSPHORYLATION; DISTRIBUTIONS;
Keywords:
stability constants; potentiometric titrations; electrospray ionization; mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: von Nagy-Felsobuki, EI Univ Newcastle, Sch Biol & Chem Sci, Callaghan, NSW2308, Australia Univ Newcastle Callaghan NSW Australia 2308 tralia
Citazione:
Sutrisno et al., "Determination of acid dissociation constants of neamine by potentiometric and electrospray mass spectral techniques", STRUCT CHEM, 12(2), 2001, pp. 189-195

Abstract

The acid dissociation constants of neamine have been measured using potentiometric titrations. The pK(a1), pK(a2), and pK(a3) values of neamine are 6.35 +/- 0.2, 7.73 +/- 0.15, and 8.62 +/- 0.08, respectively. Neamine is readily characterized using positive-ion electrospray ionization-mass spectrometry (ESI-MS). Various protonated species and their solvated ions are mainly observed. Nevertheless, the abundances of the observed speciation over the pH range 5.0-9.8 do not reflect the variation in the bulk solution. Hence, reaction quotients determined from the ESI-MS investigations vary significantly from the pK(a)'s determined from potentiometric titrations, thereby illustrating that care must be taken in determining thermodynamic properties using the former technique.

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Documento generato il 24/01/20 alle ore 12:21:22